First-generation histamine H 1-receptor antagonists, such as diphenhydramine, triprolidine,
hydroxyzine or chlorpheniramine (chlorphenamine), frequently cause somnolence or other …

Background Dimenhydrinate (DMH) is an antihistamine used to treat nausea and vomiting.
Although widely available in pharmacies as an over the counter medication, there have …

Clinical reports and animal experiments indicate that both cocaine administration and
cocaine withdrawal increase anxiety. We investigated the ability of a number of putative …

A recent series of studies in rats has demonstrated positively reinforcing and memory
enhancing effects following lesions of the nucleus tuberomammillaris, which is the only …

Diphenhydramine is generally considered an innocuous drug with a minimal risk for abuse
and untoward side effects. We describe children and adolescents with chronic hematologic …

Dimenhydrinate may be a relatively common yet unrecognized substance of abuse among
adolescents. Abuse of this drug may present as a psychiatric syndrome, particularly …

C ough and cold remedies often contain central nervous system stimulants such as phenyl-
propanolamine. This particular stimulant appears to have great potential for being abused'-4 …

C ases of antihistamine abuse have been reported only rarely. 1-4 However, we have had
several patients tell us of repeatedly ingesting large doses of dimenhydrinate (Gravol) to" get …

DISCUSSION Our patient posed a diagnostic conundrum. Her diagnosis on referral was
schizophrenia, paranoid type, severe, with treatment resistance. Records from prior …

Presents the case of a 39-yr-old woman referred to a psychiatry consultation-liaison service
for management of chronic pain. The S had an addiction to both opiates and …