Nicotine underlies tobacco addiction, influences tobacco use patterns, and is used as a
pharmacological aid to smoking cessation. The absorption, distribution and disposition …

Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for
smoking cessation, a potential medication for several diseases, and a useful probe drug for …

Nicotine inhaled in smoke is the most rapid form of delivery of the drug. With smoking,
arterial boli and high venous blood nicotine concentrations are produced within seconds …

Objective.—To evaluate the efficacy of a new nicotine inhaler system for smoking cessation.
Design.—A 1-year, randomized, double-blind, placebo-controlled study. Setting.—Medical …

Background. The use of nicotine chewing gum combined with psychological support
improves the success rate in quitting smoking. We studied the safety and efficacy of a …

Cigarette smoke is composed of many com-pounds, both solid and gaseous. Because
nicotine is the most important compound in terms of the central nervous system and vascular …

Nicotine intake is considered to be a major factor in sustaining tobacco addiction. For this
reason, nicotine gum has recently been introduced as an adjuvant to smoking cessation …

Rapid drug delivery (arterial 'boli') and high drug concentrations occur with nicotine inhaled
in smoke. These are believed to be key elements in producing addiction to cigarettes …

We studied the effectiveness of chewing gum containing nicotine, in combination with group
counseling, for subjects who were attempting to stop smoking. We used the Horn–Russell …

This study assessed the efficacy and safety of a nicotine sublingual tablet in smoking
cessation in a randomized, double-blind, placebo-controlled outpatient trial conducted …