An understanding of the pathophysiology of lactic acidosis is crucial in facilitating the optimal
care of critically ill patients. The relevant biochemistry of lactic acidosis is reviewed, and the …

Lactic acidosis is common in critically ill patients and is usually caused by tissue perfusion
that is inadequate to meet metabolic demand. However, it has also been noted in conditions …

Lactic acidosis is a life‐threatening disorder in some cases. Treatment should be directed at
the primary cause. Sodium bicarbonate should be added if the acidosis is very severe, or if …

Methanol mass poisoning is a global problem with high fatality rates and often severe
sequelae in survivors. Patients typically present late to the hospital with severe metabolic …

Alcoholic ketoacidosis (AKA) was first described by Dillon, Dyer, and Smelo in 1940. 21 A
syndrome that still may be underdiagnosed since the signs and symptoms were initially …

We have compared the capacity of major organs to produce lactic acid from endogenous
sources relative to their ability to buffer that proton load. We deduced that the ultimate source …

John J Flaherty, MD: A 51-year-old man presented to the emergency department with a chief
complaint of nausea, vomiting, abdominal pain, and shortness of breath. The patient had …

In this case report we try to illustrate the importance of correct diagnostic reasoning and the
misleading features of point-of-care testing. This case illustrates that even though …

Despite centuries of research and clinical work, the diagnosis of diabetes was still treated as
a quick death sentence at the beginning of the 20th century. Unfortunately, the number of …

In critically ill patients with sepsis or septic shock, the presence of a high anion gap
metabolic acidosis (HAGMA) is commonly attributed to lactic acidosis (1). However, studies …