DNA damage repair mechanisms are vital to maintain genomic integrity. Mutations in genes
involved in the DNA damage response (DDR) can increase the risk of developing cancer. In …

Werner's syndrome is a rare, autosomal recessive condition with multiple progeroid features,
but it is an imitation of aging rather than accelerated or premature senescence. Somatic …

Skin fibroblast-like (FL) cells from patients with Werner's syndrome (adult progeria) regularly
demonstrate frequent pseudodiploidy involving variable structural rearrangements that are …

Disorders of Connective Tissue Page 1 CHAPTER 45 Disorders of Connective Tissue NP
Burrows1 & CR Lovell2 1Department of Dermatology, Addenbrooke’s Hospital, Cambridge …

We have reviewed the world's literature that addresses familial leukemia, lymphoma, and
myeloma. We have catalogued the phenotypic abnormalities associated with an increased …

The growth of 20 independently derived skin fibroblastlike (FL) cell strains from three
individuals with Werner syndrome (adult progeria) was compared with the growth of ten FL …

All tumors classified by the Connecticut Tumor Registry which had a single peak incidence
at age greater than 50 were found to have similar patterns of incidence as a function of age …

Purpose.: DNA damage is critical in the pathogenesis of age-related cataract (ARC). This
study examined the association of copy number variations (CNVs) of DNA repair genes with …

Despite a burgeoning number of recent investigations and increasingly rigorous scrutiny, a
universally acceptable definition of normal biological aging is still not available. The origins …

The authors report a case of Werner's syndrome complicated by quintuplicate malignancy,
and review the literature data. Four malignancies occured synchronously in the case …