Hypertension is a major risk factor for cardiovascular disease, but control of hypertension
remains inadequate, often because of poor patient adherence to prescribed medical …

Objective In order to search for metabolic biomarkers of antihypertensive drug
responsiveness, we measured> 600 biochemicals in plasma samples of subjects …

Twenty-seven patients with hypertension were randomly allocated to a 10 month crossover
study. Treatment consisted of spironolactone (200 mg/day for 2 months), propranolol (320 …

In a crossover study 32 patients with hypertension were randomly allocated to treatment with
spironolactone 200 mg/day for two months, propranolol 320 mg/day for two months, and a …

The antihypertensive effect of spironolactone was studied in 20 patients with essential
hypertension and normal stimulated peripheral renin activity (PRA). Single‐blind 8‐wk …

A range of bolus doses of 14 C-chlorothiazide and unlabeled drug (6.7–30 mg/kg) were
administered to each of three unanesthetized rhesus monkeys with and without concurrent …

In North America, diuretics remain the most common first-line drug therapy for essential
hypertension based on efficacy, safety and cost. The promotion of step-care programmes …

Hypokalemia, a common complication of diuretic therapy, is commonly treated by the use of
the diuretic combinations Aldactazide and Dyazide. A crossover study was conducted in …

In a single blind crossover trial, spironolactone (50 mg twice a day), and hydrochlorothiazide
(50 mg twice a day) were equally effective hypotensive agents in 16 patients with untreated …

Epidemiological studies have shown that that there is a linear rise in mortality with
increasing levels of systolic and diastolic blood pressure (BP)[1]. Although there is no …