User profiles for Zuhier Awan
 | Dr Zuhier Awan, MD, PhD, FRCPC, FACEProfessor of Medicine, University of Jeddah Verified email at kau.edu.sa Cited by 4014 |
PCSK9: a key modulator of cardiovascular health
Since the discovery of proprotein convertase subtilisin kexin 9 (PCSK9) in 2003, this PC has
attracted a lot of attention from the scientific community and pharmaceutical companies. …
attracted a lot of attention from the scientific community and pharmaceutical companies. …
Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue
A Roubtsova, MN Munkonda, Z Awan… - … , and vascular biology, 2011 - Am Heart Assoc
Objective— Proprotein convertase subtilisin/kexin 9 (PCSK9) promotes the degradation of
the low-density lipoprotein receptor (LDLR), and its gene is the third locus implicated in …
the low-density lipoprotein receptor (LDLR), and its gene is the third locus implicated in …
The HDL proteome in acute coronary syndromes shifts to an inflammatory profile
Inflammation is a major factor underlying acute coronary syndromes (ACS). HDL particles
may be remodeled, becoming functionally defective, under the inflammatory conditions seen …
may be remodeled, becoming functionally defective, under the inflammatory conditions seen …
Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial
BACKGROUND Although statin therapy is known to increase concentrations of PCSK9,
whether this effect is related to the magnitude of LDL reduction is uncertain. This study was …
whether this effect is related to the magnitude of LDL reduction is uncertain. This study was …
PCSK9 and inflammation: a review of experimental and clinical evidence
Proprotein convertase subtilisin/kexin Type 9 (PCSK9) is now identified as an important and
major player in hypercholesterolaemia and atherosclerosis pathophysiology. PCSK9, …
major player in hypercholesterolaemia and atherosclerosis pathophysiology. PCSK9, …
[HTML][HTML] RETRACTED: Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells
Icariin (ICA) is a flavonol glycoside that has pleiotropic pharmacological actions. It has
cytotoxic effects against ovarian cancer cells and increases their chemosensitivity to …
cytotoxic effects against ovarian cancer cells and increases their chemosensitivity to …
Vascular calcifications in homozygote familial hypercholesterolemia
Background— Patients with homozygous familial hypercholesterolemia (hmzFH) attributable
to LDL receptor gene mutations have shown a remarkable increase in survival over the last …
to LDL receptor gene mutations have shown a remarkable increase in survival over the last …
APOE p. Leu167del mutation in familial hypercholesterolemia
Background Autosomal dominant hypercholesterolemia (ADH) is caused by mutations in the
low density lipoprotein receptor (LDLR), its ligand apoB (APOB) or proprotein convertase …
low density lipoprotein receptor (LDLR), its ligand apoB (APOB) or proprotein convertase …
[HTML][HTML] Electrospun nanofiber composites for drug delivery: A review on current progresses
A medication’s approximate release profile should be sustained in order to generate the
desired therapeutic effect. The drug’s release site, duration, and rate must all be adjusted to the …
desired therapeutic effect. The drug’s release site, duration, and rate must all be adjusted to the …
[HTML][HTML] Repurposing of some natural product isolates as SARS-COV-2 main protease inhibitors via in vitro cell free and cell-based antiviral assessments and …
The emergence of the SARS-CoV-2 pandemic has prompted scientists to search for an efficient
antiviral medicine to overcome the rapid spread and the marked increase in the number …
antiviral medicine to overcome the rapid spread and the marked increase in the number …