Twenty percent of the familial form of amyotrophic lateral sclerosis (ALS) is caused by
mutations in the Cu, Zn-superoxide dismutase gene (SOD1) through the gain of a toxic function. …

Interest in serotonergic involvement in Parkinson's disease (PD) has focussed recently on the
possibility that the remaining serotonin neurons innervating striatum (caudate and putamen…

The antioxidant enzyme Cu,Zn‐superoxide dismutase (SOD1) has the distinction of being
one of the most abundant disulfide‐containing protein known in the eukaryotic cytosol; …

The eukaryotic copper,zinc superoxide dismutases are remarkably stable dimeric proteins
that maintain an intrasubunit disulfide bond in the reducing environment of the cytosol and are …

Mutant forms of Cu,Zn-superoxide dismutase (SOD1) that cause familial amyotrophic lateral
sclerosis (ALS) exhibit toxicity that promotes the death of motor neurons. Proposals for the …

The transactivation response element (TAR) DNA-binding protein-43 (TDP-43) is a nuclear
protein that normally regulates transcription and splicing. Abnormal accumulation of …

We have previously shown that a fraction of yeast copper/zinc-superoxide dismutase (SOD1)
and its copper chaperone CCS localize to the intermembrane space of mitochondria. In the …

Point mutations in Cu, Zn-superoxide dismutase (SOD1) cause a familial form of the
neurodegenerative disease amyotrophic lateral sclerosis (ALS). Aggregates of mutant SOD1 …

Dominant mutations in Cu,Zn-superoxide dismutase (SOD1) cause a familial form of amyotrophic
lateral sclerosis (fALS), and aggregation of mutant SOD1 has been proposed to play a …

α-Synuclein is a major component of Lewy bodies and glial cytoplasmic inclusions,
pathological hallmarks of idiopathic Parkinson's disease and multiple system atrophy, and it is …