Importance Clinicians, patients, and policy makers rely on published results from clinical
trials to help make evidence-informed decisions. To critically evaluate and use trial results, …

BACKGROUND & AIMS: The relative efficacies of licensed antiviral therapies for treatment-naive
chronic hepatitis B (CHB) infection in randomized controlled trials have not been …

Purpose: To compare the cost-effectiveness of different imaging strategies in the diagnosis of
pediatric appendicitis by using a decision analytic model. Materials and Methods: Approval …

With the growth in the use of health economic evaluation to inform healthcare resource
allocation decisions, the challenges in applying standard methods to child health have become …

Importance Complete information in a trial protocol regarding study outcomes is crucial for
obtaining regulatory approvals, ensuring standardized trial conduct, reducing research waste, …

As healthcare expenditures continue to rise, financial pressures have resulted in a desire
for countries to shift resources away from traditional areas of spending. The consequent …

Background Seasonal influenza immunization programs vary widely across jurisdictions. In
Canada, some provinces offer universal programs while others target specific population …

Objective A significant proportion of children with autism spectrum disorder (ASD) will develop
an anxiety disorder during childhood. Restricted and repetitive behavior severity in ASD …

There is growing interest in pediatric decision science, spurred by policies advocating for
children’s involvement in medical decision making. Challenges specific to pediatric decision …

Clinical guidance documents play an important role in ensuring access to high-quality
autism spectrum disorder diagnostic assessment practices. The objective was to perform a …