The goal of this pilot study was to explore the putative molecular mechanisms underlying
the phenotypic discordance of monozygotic (MZ) twins. Thus, patterns of epigenetic DNA …

Variability among individuals in their therapeutic response to psychotropic drugs and in
susceptibility to adverse effects is considerable. Pharmacogenetics addresses the contribution of …

Atypical antipsychotics such as clozapine represent a significant improvement over typical
antipsychotics in the treatment of schizophrenia, particularly regarding extrapyramidal …

The estimated percentage of persons with schizophrenia who are overweight is higher than
the percentage of persons in the general population who are overweight. The increased …

In 112 schizophrenic patients previously treated with typical neuroleptics, we investigated
the putative role of the dopamine D3 receptor gene (DRD3) in tardive dyskinesia (TD). …

BACKGROUND: We recently described a preliminary association between the hypofunctional
seven-repeat allele of the dopamine-4 receptor gene (DRD4) and increased maximal …

Tardive dyskinesia (TD) is an important limiting factor in the use of typical antipsychotic drugs.
Genetic variability in the serotonin 2A (5-HT 2A ) receptor may influence risk for TD but the …

Sir—GP Reynolds and colleagues (June 15, p 2086) 1 report an association between
antipsychoticdrug-induced weight gain and carriage of the 5-hydroxytryptamine type 2C (5HT2C) …

There is strong evidence to suggest that genetic variation plays an important role in inter-individual
differences in medication response and toxicity. The rapidly evolving disciplines of …

There is significant evidence that altered dopamine activity plays a role in seasonal affective
disorder (SAD). The current study examined three separate genetic hypotheses for SAD …