The rates and biological significance of somatic mutations have long been a subject of debate.
Somatic mutations in plants are expected to accumulate with vegetative growth and time, …

Genome in a Bottle benchmarks are widely used to help validate clinical sequencing pipelines
and develop variant calling and sequencing methods. Here we use accurate linked and …

Polymorphic inversions are ubiquitous in humans and they have been linked to both
adaptation and disease. Following their discovery in Drosophila more than a century ago, …

Hundreds of loci in human genomes have alleles that are methylated differentially according
to their parent of origin. These imprinted loci generally show little variation across tissues, …

Single-cell Strand-seq generates directional genomic information to study DNA repair, assemble
genomes, and map structural variation onto chromosome-length haplotypes. We report …

Background Single cell Strand-seq is a unique tool for the discovery and phasing of genomic
inversions. Conventional methods to discover inversions with Strand-seq data are blind to …

Dense local haplotypes can now readily be extracted from long-read or droplet-based sequence
data. However, these methods struggle to combine subchromosomal haplotype blocks …

Mammalian genomes encode over a hundred different helicases, many of which are implicated
in the repair of DNA lesions by acting on DNA structures arising during DNA replication, …

Canadians Out of Bounds to the man’s family. We don’t have a designated quiet room in the
emergency department for discussion of catastrophic events. A 3-way conversation ensued …

Worlds Exhibition, 2003.© Prof. Dr. Gunther von Hagens, Institut für Plastination, Heidelberg,
Germany. www. bodyworlds. com into bones; the heart is a muscular pump connected to a …