Background Patient-centered care ideally considers patient preferences, values and needs.
However, it is unclear if policies such as wait time strategies for hip and knee replacement …

Background: Genome-wide sequencing has emerged as a promising strategy for the timely
diagnosis of rare diseases, but it is not yet available as a clinical test performed in Canadian …

Purpose Demonstrating the clinical utility of genetic testing is fundamental to clinical adoption
and reimbursement, but standardized definitions and measurement strategies for this …

Purpose Despite the public health successes of newborn bloodspot screening, uncertainty
associated with variant forms of primary screening targets has led to discrepancies in medical …

Objective To evaluate outcome expectations of patients undergoing revision total knee
replacement (TKR) and to examine personal factors, patient functioning, previous experiences …

Purpose To facilitate robust economic analyses of clinical exome and genome sequencing,
this study was taken up with the objective of establishing a framework for organizing …

Purpose Although costly, genome-wide sequencing (GWS) detects an extensive range of
variants, enhancing our ability to diagnose and assess risk for an increasing number of …

Objectives Recent evidence suggests that patient factors can influence response to medical
and surgical treatment and may play an under-recognized role in predicting treatment …

Methods Using a multicenter, prospective observational cohort design, we collected clinical
utility data on patients from seven clinical genetics centers in two provinces who met …

Methods GSO uses a hub-and-spoke model to provide clinical GWS, in the form of exome (ES)
and genome sequencing (GS), to Ontarians with a suspected rare disease. Sequencing …