OBJECTIVE: To design a functional, patient-centered model of patient complexity with
practical applicability to analytic design and clinical practice. Existing literature on patient …

Importance Reducing early (<30 days) hospital readmissions is a policy priority aimed at
improving health care quality. The cumulative complexity model conceptualizes patient context. …

Background Theories are important tools in the social and natural sciences. The methods by
which they are derived are rarely described and discussed. Normalization Process Theory …

Background Although guidelines for critical appraisal of diagnostic research and meta-analyses
have already been published, these may be difficult to understand for clinical …

Overwhelming evidence shows the quality of reporting of randomised controlled trials (RCTs)
is not optimal. Without transparent reporting, readers cannot judge the reliability and …

Objective: The objective of the study was to develop clinical practice guidelines for the
diagnosis of Cushing's syndrome. Participants: The Task Force included a chair, selected by the …

Objectives : The purpose of this research was to assess the association between the
metabolic syndrome (MetSyn) and cardiovascular events and mortality by meta-analyses of …

Objective: Our objective was to update the guidelines for the evaluation and treatment of
androgen deficiency syndromes in adult men published previously in 2006. Participants: The …

ContextTumor necrosis factor (TNF) plays an important role in host defense and tumor growth
control. Therefore, anti-TNF antibody therapies may increase the risk of serious infections …

GRADE suggests that examination of 95% confidence intervals (CIs) provides the optimal
primary approach to decisions regarding imprecision. For practice guidelines, rating down the …