Objectives To quantify and compare potential benefits (subjective reports of sleep variables)
and risks (adverse events and morning-after psychomotor impairment) of short term …

The goal of this review is to familiarize the reader about the potential involvement of the
brain reward system (BRS) in symptoms of Major Depressive Disorder (MDD). The authors …

… Naranjo CA, Pontigo E, Valdenegro C, Gonzalez G, Ruiz I, Busto U: Furosemide-induced
adverse reactions in cirrhosis of the liver. CLIN PHARMACOL THER 25:154-160, 1979. Seidl …

The present review discusses the available data on the kinetic properties of non-opiate abused
drugs including psychomotor stimulants, hallucinogens and CNS-depressants. Some of …

We conducted a double-blind, placebo-controlled trial in which 40 patients who had undergone
long-term therapy with benzodiazepines were switched to placebo or to diazepam in a …

Context The pathophysiology of major depressive disorder (MDD) includes disturbances in
several neuroanatomical substrates and neurotransmitter systems. The challenge is to …

The validity of the Geriatric Depression Scale (GDS) short form was assessed in a geriatric
affective disorders outpatient clinic (N = 116). The GDS was highly correlated with the …

Background The state of the brain reward system in major depressive disorder was
assessed with dextroamphetamine, which probes the release of dopamine within the …

… Urine samples (1.0 ml) were hydrolyzed overnight at pH 5.0 with 2000 U P-glucuronidase
at … Plasma samples (2.0 ml) were hydrolyzed overnight at pH 5.0 with 4000 U P-glucuronidase …

… Bruna Brands a b , Joan Blake a , Beth Sproule a c d , Douglas Gourlay a , Usoa Busto a
b d … Work conducted by our group through inpatient chart reviews (Busto et al., 1998) or by …