Activation of presynaptic P2X7-like receptors depresses mossy fiber–CA3 synaptic transmission through p38 mitogen-activated protein kinase

JN Armstrong, TB Brust, RG Lewis… - Journal of …, 2002 - Soc Neuroscience
P2X 7 receptor subunits form homomeric ATP-gated, calcium-permeable cation channels.
In this study, we used Western blots and immunocytochemistry to demonstrate that P2X 7 …

p38 mitogen-activated protein kinase contributes to adenosine A1 receptor-mediated synaptic depression in area CA1 of the rat hippocampus

TB Brust, FS Cayabyab, N Zhou… - Journal of …, 2006 - Soc Neuroscience
Adenosine is arguably the most potent and widespread presynaptic modulator in the CNS,
yet adenosine receptor signal transduction pathways remain unresolved. Here, we …

Neuromyelitis optica spectrum disorder presenting with concurrent autoimmune diseases

VC Bibic, TB Brust, JM Burton - Multiple sclerosis and related disorders, 2019 - Elsevier
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune syndrome characterized
by optic nerve and spinal cord inflammation. In recent years, there has been increasing …

C-Jun N-terminal kinase regulates adenosine A1 receptor-mediated synaptic depression in the rat hippocampus

TB Brust, FS Cayabyab, BA MacVicar - Neuropharmacology, 2007 - Elsevier
Adenosine A1 receptors are ubiquitous mediators of presynaptic inhibition of neurotransmission
in the central nervous system, yet the signalling pathway linking A1 receptor activation …

Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia

GO Iyirhiaro, TB Brust, J Rashidian… - Journal of …, 2008 - Wiley Online Library
We previously reported that delayed administration of the general cyclin‐dependent kinase
inhibitor flavopiridol following global ischemia provided transient neuroprotection and …

[HTML][HTML] Whose body is this?

TB Brust - CMAJ, 2014 - Can Med Assoc
I first wondered whether I had amyotrophic lateral sclerosis in the summer of 2013. I was
pouring coffee and dropped the coffee pot on the table. My right shoulder just gave out. Why did …

Purinergic modulation of neurotransmission

TB Brust - 2006 - open.library.ubc.ca
Tyson B reman Brust … Gs/oif protein-coupled adenosine receptor A 2 B … PI receptors
include the A i, A 2 A, A 2 B, and A 3 subtypes, each of which has a distinct tissue distribution, …

Damage model prediction of crack initiation and propagation in five fracture geometries for X80 pipeline steel

…, S Xu, DY Park, WR Tyson - Journal of …, 2022 - asmedigitalcollection.asme.org
Test specimens used to calibrate damage-mechanics models are designed to produce a
range of stress triaxialities and Lode angles to accurately capture the fracture envelope of the …

Multiple immune-related adverse event overlap in two patients treated with pembrolizumab

…, C Camara-Lemarroy, JT Joseph, T Brust - Canadian Journal of …, 2022 - cambridge.org
… Her CT chest was in keeping with pneumonitis (Figure 1B). She was diagnosed with overlapping
MG, IM, myocarditis, pneumonitis, hepatitis, and autoimmune thyroiditis presumed to be …

Finite element analysis to investigate the effect of loading modes on the CTOA of DWTT specimens

J Xue, B Williams, S Xu, WR Tyson - Procedia Structural Integrity, 2020 - Elsevier
… CTOA shows little change between 0.5 mm and 3 mm, but increases slightly at 7 mm (B/2), …
At distances larger than 10 mm (0.7B), the CTOA on the surface becomes larger than that in …