BACKGROUND: Filaggrin is a key protein involved in skin barrier function. Recently, mutations
in the filaggrin gene, FLG, were identified in European families with ichthyosis vulgaris (IV…

The sphingolipid backbone ceramide (Cer) is a major component of lipid lamellae in the
stratum corneum of epidermis and has a pivotal role in epidermal barrier formation. Unlike Cers …

Palmoplantar keratodermas (PPKs) are a group of disorders that are diagnostically and
therapeutically problematic in dermatogenetics 1 , 2 , 3 . Punctate PPKs are characterized by …

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening,
cutaneous adverse drug reactions that are accompanied by keratinocyte cell death. Dead …

Mutations in the gene-encoding filaggrin (FLG), a key molecule involved in skin barrier function,
have been shown to be a major predisposing factor for atopic dermatitis (AD; eczema). …

The drug molecule PTC124 (Ataluren) has been described as a read-through agent, capable
of suppressing premature termination codons (PTCs) and restoring functional protein …

Mutations in the gene encoding filaggrin (FLG) have been identified as the cause of
ichthyosis vulgaris (IV) and shown to be major predisposing factors for atopic dermatitis (AD). …

Background The stratum corneum and tight junctions (TJs) form physical barriers in the
epidermis. Dendrites of activated Langerhans cells (LCs) extend beyond the TJs to capture …

BACKGROUND: Atopic dermatitis (AD) can be classified into the major extrinsic type with
high serum IgE levels and impaired barrier, and the minor intrinsic type with normal IgE levels …

The mechanosensitive channel of small conductance (MscS) has been characterized at both
functional and structural levels and has an integral role in the protection of bacterial cells …