Shock and tissue injury induced by recombinant human cachectin
…, S Wolpe, IW Milsark, RJ Hariri, TJ Fahey III… - Science, 1986 - science.org
Cachectin (tumor necrosis factor), a protein produced in large quantities by endotoxin-activated
macrophages, has been implicated as an important mediator of the lethal effect of …
macrophages, has been implicated as an important mediator of the lethal effect of …
[HTML][HTML] Is the Timed Up and Go test a useful predictor of risk of falls in community dwelling older adults: a systematic review and meta-analysis
Background The Timed Up and Go test (TUG) is a commonly used screening tool to assist
clinicians to identify patients at risk of falling. The purpose of this systematic review and meta-…
clinicians to identify patients at risk of falling. The purpose of this systematic review and meta-…
Antibiotics for acute bronchitis
Background The benefits and risks of antibiotics for acute bronchitis remain unclear despite
it being one of the most common illnesses seen in primary care. Objectives To assess the …
it being one of the most common illnesses seen in primary care. Objectives To assess the …
Interventions used to improve control of blood pressure in patients with hypertension
Background Patients with high blood pressure (hypertension) in the community frequently
fail to meet treatment goals‐a condition labelled as" uncontrolled" hypertension. The optimal …
fail to meet treatment goals‐a condition labelled as" uncontrolled" hypertension. The optimal …
Predictive accuracy of the Framingham coronary risk score in British men: prospective cohort study
Objective To establish the predictive accuracy of the Framingham risk score for coronary heart
disease in a representative British population. Design Prospective cohort study. Setting 24 …
disease in a representative British population. Design Prospective cohort study. Setting 24 …
Managing patients with multimorbidity in primary care
Multimorbidity, commonly defined as the presence of two or more chronic medical conditions
in an individual, 1 is associated with decreased quality of life, functional decline, and …
in an individual, 1 is associated with decreased quality of life, functional decline, and …
Potentially inappropriate prescribing and cost outcomes for older people: a national population study
C Cahir, T Fahey, M Teeling, C Teljeur… - British journal of …, 2010 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Potentially inappropriate prescribing
(PIP) refers to medications that should generally be avoided in older populations and doses …
(PIP) refers to medications that should generally be avoided in older populations and doses …
[HTML][HTML] The Alvarado score for predicting acute appendicitis: a systematic review
Background The Alvarado score can be used to stratify patients with symptoms of suspected
appendicitis; the validity of the score in certain patient groups and at different cut points is …
appendicitis; the validity of the score in certain patient groups and at different cut points is …
Accuracy and impact of risk assessment in the primary prevention of cardiovascular disease: a systematic review
Objective: To determine the accuracy of assessing cardiovascular disease (CVD) risk in the
primary prevention of CVD and its impact on clinical outcomes. Design: Systematic review. …
primary prevention of CVD and its impact on clinical outcomes. Design: Systematic review. …
The expanding role of primary care in cancer control
The nature of cancer control is changing, with an increasing emphasis, fuelled by public and
political demand, on prevention, early diagnosis, and patient experience during and after …
political demand, on prevention, early diagnosis, and patient experience during and after …