[HTML][HTML] Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial

…, J Powis, J McCready, DHS Tan, T Chan… - The Lancet …, 2021 - thelancet.com
Background To date, only monoclonal antibodies have been shown to be effective for
outpatients with COVID-19. Interferon lambda-1 is a type III interferon involved in innate antiviral …

Racial/ethnic disparities in genomic sequencing

DE Spratt, T Chan, L Waldron, C Speers… - JAMA …, 2016 - jamanetwork.com
Importance Although poorly understood, there is heterogeneity in the molecular biology of
cancer across race and ethnicities. The representation of racial minorities in large genomic …

[PDF][PDF] Integrated (epi)-genomic analyses identify subgroup-specific therapeutic targets in CNS rhabdoid tumors

J Torchia, B Golbourn, S Feng, KC Ho, P Sin-Chan… - Cancer cell, 2016 - cell.com
We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two
transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying …

Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis

…, YS Ra, KC Ho, TSY Chan, P Sin-Chan… - The lancet …, 2015 - thelancet.com
Background Rhabdoid brain tumours, also called atypical teratoid rhabdoid tumours, are
lethal childhood cancers with characteristic genetic alterations of SMARCB1/hSNF5. Lack of …

Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis

…, CE Hawkins, E Bouffet, HA Rogers, TSY Chan… - The lancet …, 2012 - thelancet.com
Background Childhood CNS primitive neuro-ectodermal brain tumours (PNETs) are very
aggressive brain tumours for which the molecular features and best treatment approaches are …

Characterizing functional complaints in patients seeking outpatient low-vision services in the United States

JC Brown, JE Goldstein, TL Chan, R Massof, P Ramulu… - Ophthalmology, 2014 - Elsevier
Purpose To characterize functional complaints of new low-vision rehabilitation patients.
Design Prospective observational study. Participants The Low Vision Rehabilitation Outcomes …

Estimates of incidence and prevalence of visual impairment, low vision, and blindness in the United States

T Chan, DS Friedman, C Bradley… - JAMA …, 2018 - jamanetwork.com
Importance Updated estimates of the prevalence and incidence rates of low vision and
blindness are needed to inform policy makers and develop plans to meet the future demands for …

Addressing burnout in radiologists

AL Chetlen, TL Chan, DH Ballard, LA Frigini… - Academic radiology, 2019 - Elsevier
Burnout is a global health problem affecting physicians across all medical specialties.
Radiologists, in particular, experience high rates of burn out, and this trend has only continued to …

Critical role of natural killer cells in lung immunopathology during influenza infection in mice

…, NG Barra, MV Chew, T Chan… - The Journal of …, 2012 - academic.oup.com
Influenza viral infection results in excessive pulmonary inflammation that has been linked to
the damage caused by immune responses and viral replication. The multifunctional cytokine …

Diverticulitis: an update from the age old paradigm

AT Hawkins, PE Wise, T Chan, JT Lee, T Glyn… - Current problems in …, 2020 - Elsevier
Regardless of how the problem is examined, diverticular disease is a significant burden for
both patients and healthcare systems. In Western and industrialized nations, diverticulosis of …