miRNAs were recently implicated in the pathogenesis of numerous diseases, including
neurological disorders such as Parkinson's disease (PD). miRNAs are abundant in the nervous …

Background Huntington's disease (HD) is an orphan autosomal dominant neurodegenerative
disorder caused by the amplification of a nucleic acids triplet repeat. It is characterised by …

Background Essential tremor is one of the most prevalent movement disorders. Many
treatments for essential tremor have been reported in clinical practice, but it is uncertain which …

Early descriptions of subtypes of Parkinson's disease (PD) are dominated by the approach of
predetermined groups. Experts defined, from clinical observation, groups based on clinical …

The current research paradigm for Huntington's disease is based on participants with overt
clinical phenotypes and does not address its pathophysiology nor the biomarker changes …

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin
gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis …

Obtaining reliable longitudinal information about everyday functioning from individuals with
Parkinson's disease (PD) in natural environments is critical for clinical care and research. …

Background Cognitive impairment is a common nonmotor manifestation of Parkinson's disease,
with deficits ranging from mild cognitive difficulties in 1 or more of the cognitive domains …

Importance Urate elevation, despite associations with crystallopathic, cardiovascular, and
metabolic disorders, has been pursued as a potential disease-modifying strategy for …

Background The study of complex neurodegenerative diseases is moving away from
hypothesis‐driven biological methods toward large scale multimodal approaches, requiring …