OBJECTIVE: Current estimates of the prevalence of depression during pregnancy vary widely.
A more precise estimate is required to identify the level of disease burden and develop …

Background Cardiovascular disease (CVD) is a common comorbidity in type 2 diabetes (T2DM).
CVD’s prevalence has been growing over time. Purpose To estimate the current …

Background: Corticosteroids are first-line drugs for the treatment of a variety of conditions in
women of childbearing age. Information regarding human pregnancy outcome with …

OBJECTIVE: To review and summarize studies reporting rates of drug-related hospital
admissions. DATA SOURCES: Manual and computerized literature searches using MEDLINE, …

Background: Cholinesterase inhibitors (ChEIs) are the only drugs marketed for the treatment
of Alzheimer's disease. Despite numerous randomized controlled trials, the efficacy and …

Objective: To determine if exposure to benzodiazepines during the first trimester of pregnancy
increases risk of major malformations or cleft lip or palate. Design Meta-analysis. Setting: …

Objective: To evaluate the safety of biological treatments for rheumatoid arthritis (RA) using
results from randomised controlled trials (RCT). Methods: The literature was searched to …

Background: Rates of patient adherence (compliance) to pharmacotherapy range from <5%
to >90%. Negative determinants include multiple daily dosing (MDD), chronic duration, and …

OBJECTIVE: Our purpose was to determine from published experience in humans whether
metronidazole exposure during the first trimester of pregnancy is associated with an …

Background The use of folic acid-fortified multivitamin supplements has long been associated
with decreasing the risk of neural tube defects. Several studies have also proposed the …