Assessing the safety and immunogenicity of recombinant vesicular stomatitis virus Ebola vaccine in healthy adults: a randomized clinical trial
…, L Li, T Racine, J Alimonti, TL Rudge… - Cmaj, 2017 - Can Med Assoc
BACKGROUND: The 2013–2016 Ebola virus outbreak in West Africa was the most
widespread in history. In response, alive attenuated recombinant vesicular stomatitis virus (rVSV) …
widespread in history. In response, alive attenuated recombinant vesicular stomatitis virus (rVSV) …
Randomized, double-blind, placebo-controlled, safety and immunogenicity study of 4 formulations of Anthrax Vaccine Adsorbed plus CPG 7909 (AV7909) in healthy …
…, D Muse, E Sheldon, C LaForce, S Sari, TL Rudge… - Vaccine, 2013 - Elsevier
A new anthrax vaccine that could accelerate the immune response and possibly reduce the
number of injections needed for protection would be desirable in a post-exposure setting. …
number of injections needed for protection would be desirable in a post-exposure setting. …
Evaluation of immunogenicity and efficacy of anthrax vaccine adsorbed for postexposure prophylaxis
…, FM Reid, KH Clement, TL Rudge Jr… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
Antimicrobials administered postexposure can reduce the incidence or progression of
anthrax disease, but they do not protect against the disease resulting from the germination of …
anthrax disease, but they do not protect against the disease resulting from the germination of …
[HTML][HTML] Inhibition of the mammalian transcription factor LSF induces S‐phase‐dependent apoptosis by downregulating thymidylate synthase expression
CMH Powell, TL Rudge, Q Zhu, LF Johnson… - The EMBO …, 2000 - embopress.org
The thymidylate synthase (TS) gene, which is induced at the G 1–S transition in growth‐stimulated
cells, encodes an enzyme that is essential for DNA replication and cell survival. Here …
cells, encodes an enzyme that is essential for DNA replication and cell survival. Here …
Preferential expression of matrix metalloproteinase‐9 in mouse skin after sulfur mustard exposure
…, YC Chang, SL Casbohm, TL Rudge… - Journal of Applied …, 2006 - Wiley Online Library
Matrix metalloproteinases (MMPs), a class of enzymes responsible for the degradation of
extracellular matrix proteins, play important roles in inflammatory and immune responses. In …
extracellular matrix proteins, play important roles in inflammatory and immune responses. In …
Development, qualification, and validation of the Filovirus Animal Nonclinical Group anti-Ebola virus glycoprotein immunoglobulin G enzyme-linked immunosorbent …
TL Rudge Jr, KA Sankovich, NA Niemuth… - PloS one, 2019 - journals.plos.org
The need for an efficacious vaccine against highly pathogenic filoviruses was reinforced by
the recent and devastating 2014–2016 outbreak of Ebola virus (EBOV) disease in Guinea, …
the recent and devastating 2014–2016 outbreak of Ebola virus (EBOV) disease in Guinea, …
Single-dose trivalent VesiculoVax vaccine protects macaques from lethal Ebolavirus and Marburgvirus challenge
…, MQS Wendling, A Burnaugh, TL Rudge Jr… - Journal of …, 2018 - Am Soc Microbiol
Previous studies demonstrated that a single intramuscular (im) dose of an attenuated
recombinant vesicular stomatitis virus (rVSV) vector (VesiculoVax vector platform; rVSV-N4CT1) …
recombinant vesicular stomatitis virus (rVSV) vector (VesiculoVax vector platform; rVSV-N4CT1) …
A three-dose intramuscular injection schedule of anthrax vaccine adsorbed generates sustained humoral and cellular immune responses to protective antigen and …
…, H Li, VA Semenova, TL Rudge… - Clinical and Vaccine …, 2012 - Am Soc Microbiol
A 3-dose (0, 1, and 6 months) intramuscular (3-IM) priming series of a human dose (HuAVA)
and dilutions of up to 1:10 of anthrax vaccine adsorbed (AVA) provided statistically …
and dilutions of up to 1:10 of anthrax vaccine adsorbed (AVA) provided statistically …
Assays for the Evaluation of the Immune Response to Marburg and Ebola Sudan Vaccination—Filovirus Animal Nonclinical Group Anti-Marburg Virus Glycoprotein …
TL Rudge Jr, NJ Machesky, KA Sankovich… - Vaccines, 2022 - mdpi.com
Since the discovery of the Marburg virus (MARV) in 1967 and Ebola virus (EBOV) in 1976,
there have been over 40 reported outbreaks of filovirus disease with case fatality rates greater …
there have been over 40 reported outbreaks of filovirus disease with case fatality rates greater …
Human cytomegalovirus infection induces cellular thymidylate synthase gene expression in quiescent fibroblasts
G Gribaudo, L Riera, TL Rudge… - Journal of general …, 2002 - microbiologyresearch.org
Productive infection of non-proliferating cells by cytomegalovirus (CMV) requires the coordinated
stimulation of host biochemical pathways that prepare cells to synthesize DNA. Here …
stimulation of host biochemical pathways that prepare cells to synthesize DNA. Here …
