The outcomes of transplantation vary widely by organ. Lung transplantation (LTx) has rather
poor long-term outcome, with a current median post-transplant survival of 6.0 years. 1, 2 …

Background: Growing numbers of critically ill patients receive prolonged mechanical ventilation.
Little is known about the patterns of care as patients transition from acute care hospitals …

Objective: To compare prolonged mechanical ventilation decision-makers’ expectations for
long-term patient outcomes with prospectively observed outcomes and to characterize …

Pathogenic COPA variants cause a Mendelian syndrome of immune dysregulation with
elevated type I interferon signaling. COPA is a subunit of coat protein complex I (COPI) that …

Despite the recent introduction of many improved immunosuppressive agents for use in
transplantation, acute rejection affects up to 55% of lung transplant recipients within the first year …

Rationale: Despite increasing evidence about the role of donor-specific human leukocyte
antigen (HLA) antibodies in transplant outcomes, the incidence and impact of de novo donor-…

Importance The mortality rate for individuals on the wait list for lung transplant is 15% to 25%,
and still only 20% of lungs from multiorgan donors are used for lung transplant. The lung …

Chronic lung allograft dysfunction (CLAD) remains a major problem after lung transplantation
with no definitive treatment except redo lung transplantation (re‐LTx) in selected …

BACKGROUND: Although electronic cigarettes (e-cigarettes) were initially marketed as a
potential smoking-cessation aid and a safer alternative to smoking, the long-term health effect …

Objectives: To examine the association of anxiety and depression with pulmonary-specific
symptoms of Chronic Obstructive Pulmonary Disease (COPD), and to determine the extent to …