OBJECTIVES: Sessile serrated adenomas (SSAs) are known to be precursors of sporadic
colorectal cancers (CRCs) with microsatellite instability (MSI), and to be tightly associated …

In recent years, a concept of renal rehabilitation has become widely known among nephrology
specialists, dialysis specialists, kidney transplantation specialists, rehabilitation specialists…

Basic helix-loop-helix (bHLH) transcription factors are known as key regulators for
mesenchymal differentiation. The present study showed that overexpression of Twist-1, a bHLH …

Acquired mutations of JAK2 and TET2 are frequent in myeloproliferative neoplasms (MPNs).
We examined the individual and cooperative effects of these mutations on MPN …

Diagnosis is one of the crucial tasks performed by primary care physicians; however,
primary care is at high risk of diagnostic errors due to the characteristics and uncertainties …

The concept of the CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) is
widely accepted, although the timing of its occurrence and its interaction with other genetic …

Acute myeloid leukemia with KMT2A (MLL) rearrangements is characterized by specific
patterns of gene expression and enhancer architecture, implying unique core transcriptional …

Background Metachronous gastric cancer (GC) can develop after endoscopic resection of
GC and cannot be predicted based on clinical signature. Aberrant DNA methylation in …

Objectives Coronavirus disease (COVID-19) blindness, that is, the excessive consideration
of the disease in diagnosis, has reportedly led to delayed diagnosis of some diseases. We …

Aberrant DNA methylation could potentially serve as a biomarker for colorectal neoplasms.
In this study, we assessed the feasibility of using DNA methylation detected in bowel lavage …