Neuroblastoma is a frequently lethal childhood tumor in which MYC gene deregulation,
commonly as MYCN amplification, portends poor outcome. Identifying the requisite biopathways …

Correcting T-cell immunosuppression may unleash powerful antitumor responses; however,
knowledge about the mechanisms and modifiers that may be targeted to improve therapy …

Malnutrition is a common complication in patients with end‐stage liver disease (ESLD) awaiting
liver transplantation (LT). Malnutrition and sarcopenia overlap in etiology and outcomes, …

Background: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease in obese
children. Diets high in added fructose (high fructose corn syrup; HFCS) and glycemic index (GI…

… Gilmour equally contributed to the conception and design of the research; PH Ooi, DR Mager,
and SM Gilmour … Thompson-Hodgetts, and SM Gilmour contributed to the interpretation of …

Ornithine decarboxylase, a critical regulatory enzyme for polyamine biosynthesis, is highly
inducible by growth-promoting stimuli in mouse epidermis but the enzyme level is only …

Neuroblastoma is a childhood tumor in which MYC oncogenes are commonly activated to
drive tumor progression. Survival for children with high-risk neuroblastoma remains poor …

Background and Aims Glecaprevir/pibrentasvir (GLE/PIB) has shown high efficacy and safety
in chronic HCV‐infected adults and adolescents; data in children were limited. DORA part …

Most tumors maintain elevated levels of polyamines to support their growth and survival. This
study explores the anti-tumor effect of polyamine starvation via both inhibiting polyamine …

Elevated levels of polyamines have long been associated with skin tumorigenesis. Tightly
regulated metabolism of polyamines is critical for cell survival and normal skin homeostasis, …