Background The effect of a restrictive versus liberal red-cell transfusion strategy on clinical
outcomes in patients undergoing cardiac surgery remains unclear. Methods In this multicenter…

Importance Patients with atrial fibrillation (AF) who use a direct oral anticoagulant (DOAC)
and request elective surgery or procedure present a common clinical situation yet …

Background Cerebral oxygen desaturation during cardiac surgery has been associated with
adverse perioperative outcomes. Before a large multicenter randomized controlled trial (…

Background We reported previously that, in patients undergoing cardiac surgery who were at
moderate-to-high risk for death, a restrictive transfusion strategy was noninferior to a liberal …

Acute kidney injury (AKI) is a potentially serious complication of cardiac surgery. Anemia and
red blood cell (RBC) transfusion have individually been identified as potentially modifiable …

Importance Excessive bleeding is a common complication of cardiac surgery. An important
cause of bleeding is acquired hypofibrinogenemia (fibrinogen level <1.5-2.0 g/L), for which …

METHODS: Patients undergoing complex cardiac surgery with CPB who did not have preexisting
coagulopathy were eligible. Detailed clinical and coagulation data were prospectively …

In this study we sought to extend the plasma half-life while maintaining the potent antithrombin
activity of hirudin. We hypothesized that gene fusion of hirudin to albumin would result in …

Background The perioperative management of patients who take a direct oral anticoagulant
(DOAC) for atrial fibrillation and require treatment interruption for an elective surgery/…

The Perioperative Anticoagulation Use for Surgery Evaluation (PAUSE) study prospectively
evaluated a prespecified periprocedural-interruption strategy of direct oral anticoagulants (…