Argonaute proteins and small interfering RNAs (siRNAs) are the known signature
components of the RNA interference effector complex RNA-induced silencing complex (RISC). …

Why do some global health initiatives receive priority from international and national political
leaders whereas others receive little attention? To analyse this question we propose a …

RISC, the RNA-induced silencing complex, uses short interfering RNAs (siRNAs) or micro
RNAs (miRNAs) to select its targets in a sequence-dependent manner. Key RISC components …

Inorganic polyphosphate is an abundant component of acidocalcisomes of bacteria and
unicellular eukaryotes. Human platelet dense granules strongly resemble acidocalcisomes, and …

Patients with COVID-19 are at high risk for thrombotic arterial and venous occlusions. Lung
histopathology often reveals fibrin-based blockages in the small blood vessels of patients …

In this Focus article, the authors ask a seemingly simple question: Are harmful algal blooms (HABs)
becoming the greatest inland water quality threat to public health and aquatic …

ContextAlthough advance directives are commonly used in the community, little is known
about the effects of their systematic implementation.ObjectivesTo examine the effect of …

The plasma coagulation system in mammalian blood consists of a cascade of enzyme activation
events in which serine proteases activate the proteins (proenzymes and procofactors) in …

Platelets play a central role in thrombosis, hemostasis, and inflammation. We show that
activated platelets release inorganic polyphosphate (polyP), a polymer of 60–100 phosphate …

Background Rectal diazepam and buccal midazolam are used for emergency treatment of
acute febrile and afebrile (epileptic) seizures in children. We aimed to compare the safety and …