Statin toxicity from macrolide antibiotic coprescription: a population-based cohort study
…, DG Bailey, DN Juurlink, S Gandhi… - Annals of internal …, 2013 - acpjournals.org
Chinese translation Background: Clarithromycin and erythromycin, but not azithromycin,
inhibit cytochrome P450 isoenzyme 3A4 (CYP3A4), and inhibition increases blood …
inhibit cytochrome P450 isoenzyme 3A4 (CYP3A4), and inhibition increases blood …
Calcium-channel blocker–clarithromycin drug interactions and acute kidney injury
S Gandhi, JL Fleet, DG Bailey, E McArthur, R Wald… - Jama, 2013 - jamanetwork.com
Importance Calcium-channel blockers are metabolized by the cytochrome P450 3A4 (CYP3A4;
EC 1.14.13.97) enzyme. Blood concentrations of these drugs may rise to harmful levels …
EC 1.14.13.97) enzyme. Blood concentrations of these drugs may rise to harmful levels …
Atypical antipsychotic drugs and the risk for acute kidney injury and other adverse outcomes in older adults: a population-based cohort study
…, JP Reiss, R Wald, CR Parikh, S Gandhi… - Annals of internal …, 2014 - acpjournals.org
Background: Several adverse outcomes attributed to atypical antipsychotic drugs, specifically
quetiapine, risperidone, and olanzapine, are known to cause acute kidney injury (AKI). …
quetiapine, risperidone, and olanzapine, are known to cause acute kidney injury (AKI). …
Validity of the International Classification of Diseases, Tenth Revision code for acute kidney injury in elderly patients at presentation to the emergency department and …
Objective To evaluate the validity of the International Classification of Diseases, Tenth
Revision (ICD-10) code N17x for acute kidney injury (AKI) in elderly patients in two settings: at …
Revision (ICD-10) code N17x for acute kidney injury (AKI) in elderly patients in two settings: at …
Validity of the International Classification of Diseases 10th revision code for hyperkalaemia in elderly patients at presentation to an emergency department and at …
JL Fleet, SZ Shariff, S Gandhi, MA Weir, AK Jain… - BMJ open, 2012 - bmjopen.bmj.com
Objectives Evaluate the validity of the International Classification of Diseases, 10th revision (ICD-10)
code for hyperkalaemia (E87.5) in two settings: at presentation to an emergency …
code for hyperkalaemia (E87.5) in two settings: at presentation to an emergency …
Risk of adverse events among older adults following co-prescription of clarithromycin and statins not metabolized by cytochrome P450 3A4
…, SZ Shariff, T Gomes, M Mamdani, S Gandhi… - Cmaj, 2015 - Can Med Assoc
Background: The cytochrome P450 3A4 (CYP3A4) inhibitor clarithromycin may also inhibit
liver-specific organic anion–transporting polypeptides (OATP1B1 and OATP1B3). We studied …
liver-specific organic anion–transporting polypeptides (OATP1B1 and OATP1B3). We studied …
Kidney function and the use of nitrofurantoin to treat urinary tract infections in older women
N Singh, S Gandhi, E McArthur, L Moist, AK Jain… - Cmaj, 2015 - Can Med Assoc
Background: The antibiotic nitrofurantoin is commonly used to treat uncomplicated urinary
tract infections. However, when this drug is used by patients with reduced kidney function, its …
tract infections. However, when this drug is used by patients with reduced kidney function, its …
Second-generation antidepressants and hyponatremia risk: a population-based cohort study of older adults
S Gandhi, SZ Shariff, A Al-Jaishi, JP Reiss… - American Journal of …, 2017 - Elsevier
Background Hyponatremia may occur after initiation of a second-generation antidepressant
drug. However, the magnitude of this risk among older adults in routine care is not well …
drug. However, the magnitude of this risk among older adults in routine care is not well …
Hyponatremia and sodium picosulfate bowel preparations in older adults
…, K Liu, H Song, AK Jain, S Gandhi… - Official journal of the …, 2014 - journals.lww.com
OBJECTIVES: Bowel preparations are commonly prescribed drugs. Case reports and our
clinical experience suggest that sodium picosulfate bowel preparations can precipitate severe …
clinical experience suggest that sodium picosulfate bowel preparations can precipitate severe …
Risk of acute kidney injury from oral acyclovir: a population-based study
…, PG Blake, MM Beyea, T Gomes, S Gandhi… - American journal of …, 2013 - Elsevier
BACKGROUND: Intravenous acyclovir-induced acute kidney injury (AKI) from drug crystallization
in the renal tubules is described in case reports, review articles, and drug prescribing …
in the renal tubules is described in case reports, review articles, and drug prescribing …