BACKGROUND: Identification of patients at high risk of death is critical for appropriate
management of patients and health care resources. The impact of repeated heart failure (HF) …

Background: Although it is known that rheumatoid arthritis is associated with an increased
risk of cardiovascular disease (CVD), the pattern of this risk is not clear. This study …

Background: Public health advisories have warned that the use of atypical antipsychotic
medications increases the risk of death among elderly patients. We assessed the short-term …

Objective: Isotonic saline is the most commonly used crystalloid in the ICU, but recent
evidence suggests that balanced fluids like Lactated Ringer’s solution may be preferable. We …

Objective To examine the association of cardiovascular events with tumour necrosis factor (TNF)
α antagonist use compared with non-biological disease-modifying antirheumatic drug (…

Background Whether the use of selective serotonin-reuptake inhibitors (SSRIs) and other
antidepressants during pregnancy is associated with an increased risk of congenital cardiac …

Rho-kinase plays an important role in modulating Ca 2+ sensitivity of vascular smooth muscle
and has been suggested to be involved in the increased systemic vascular resistance in …

Background Cardiovascular (CV) disease has a major impact on patients with rheumatoid
arthritis (RA), however, the relative contributions of traditional CV risk factors and markers of …

Objective To assess the association between the initiation of anti–tumor necrosis factor α (anti‐TNFα)
therapy and the risk of serious bacterial infections in routine care. Methods This …

Background In propensity score modeling, it is a standard practice to optimize the prediction
of exposure status based on the covariate information. In a simulation study, we examined …