Leptin gene epigenetic adaptation to impaired glucose metabolism during pregnancy
L Bouchard, S Thibault, SP Guay, M Santure… - Diabetes …, 2010 - Am Diabetes Assoc
OBJECTIVE To verify whether the leptin gene epigenetic (DNA methylation) profile is altered
in the offspring of mothers with gestational impaired glucose tolerance (IGT). RESEARCH …
in the offspring of mothers with gestational impaired glucose tolerance (IGT). RESEARCH …
Placental adiponectin gene DNA methylation levels are associated with mothers' blood glucose concentration
L Bouchard, MF Hivert, SP Guay, J St-Pierre… - Diabetes, 2012 - Am Diabetes Assoc
<p>Growing evidence suggests that epigenetic profile changes occurring during fetal
development in response to in utero environment variations could be one of the mechanisms …
development in response to in utero environment variations could be one of the mechanisms …
Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1
F Hadji, MC Boulanger, SP Guay, N Gaudreault… - Circulation, 2016 - Am Heart Assoc
Background: Calcific aortic valve disease is characterized by an abnormal mineralization of
the aortic valve. Osteogenic activity in the aortic valve is under the control of NOTCH1, which …
the aortic valve. Osteogenic activity in the aortic valve is under the control of NOTCH1, which …
IGF2 DNA methylation is a modulator of newborn's fetal growth and development
J St-Pierre, MF Hivert, P Perron, P Poirier, SP Guay… - Epigenetics, 2012 - Taylor & Francis
The insulin-like growth factor 2 (IGF2) gene, located within a cluster of imprinted genes on
chromosome 11p15, encodes a fetal and placental growth factor affecting birth weight. DNA …
chromosome 11p15, encodes a fetal and placental growth factor affecting birth weight. DNA …
ABCA1 gene promoter DNA methylation is associated with HDL particle profile and coronary artery disease in familial hypercholesterolemia
SP Guay, D Brisson, J Munger, B Lamarche… - Epigenetics, 2012 - Taylor & Francis
… During this research, Simon-Pierre Guay was recipient of a doctoral research award from
the Canadian Institutes for Health and Research (CIHR), and a master’s award from the Fonds …
the Canadian Institutes for Health and Research (CIHR), and a master’s award from the Fonds …
Adaptations of placental and cord blood ABCA1 DNA methylation profile to maternal metabolic status
AA Houde, SP Guay, V Desgagné, MF Hivert… - Epigenetics, 2013 - Taylor & Francis
In utero environmental perturbations have been associated with epigenetic changes in the
offspring and a lifelong susceptibility to cardiovascular diseases (CVD). DNA methylation at …
offspring and a lifelong susceptibility to cardiovascular diseases (CVD). DNA methylation at …
[HTML][HTML] PPARGC1α gene DNA methylation variations in human placenta mediate the link between maternal hyperglycemia and leptin levels in newborns
S Côté, V Gagné-Ouellet, SP Guay, C Allard… - Clinical …, 2016 - Springer
Background Children exposed to gestational diabetes mellitus (GDM) are at a higher risk of
developing obesity and type 2 diabetes. This susceptibility might involve brown adipose …
developing obesity and type 2 diabetes. This susceptibility might involve brown adipose …
[HTML][HTML] Acetylsalicylic acid, aging and coronary artery disease are associated with ABCA1 DNA methylation in men
SP Guay, C Légaré, AA Houde, P Mathieu, Y Bossé… - Clinical …, 2014 - Springer
Background Previous studies have suggested that DNA methylation contributes to coronary
artery disease (CAD) risk variability. DNA hypermethylation at the ATP-binding cassette …
artery disease (CAD) risk variability. DNA hypermethylation at the ATP-binding cassette …
[HTML][HTML] Human plasma pregnancy-associated miRNAs and their temporal variation within the first trimester of pregnancy
…, V Desgagné, K Thibeault, F White, SP Guay… - Reproductive Biology …, 2022 - Springer
Background During pregnancy, maternal metabolism undergoes substantial changes to
support the developing fetus. Such changes are finely regulated by different mechanisms …
support the developing fetus. Such changes are finely regulated by different mechanisms …
Epipolymorphisms within lipoprotein genes contribute independently to plasma lipid levels in familial hypercholesterolemia
SP Guay, D Brisson, B Lamarche, D Gaudet… - Epigenetics, 2014 - Taylor & Francis
… Simon-Pierre Guay was recipient of a doctoral research award from the Canadian Institutes
for Health and Research (CIHR). During this study, Dr Daniel Gaudet held the Canada …
for Health and Research (CIHR). During this study, Dr Daniel Gaudet held the Canada …
