Background Alpha‐synuclein plays a central role in the pathophysiology of Parkinson's
disease. Three missense mutations in SNCA, the gene encoding alpha‐synuclein, as well as …

Almost half the cells and 1% of the unique genes found in our bodies are human, the rest are
from microbes, predominantly bacteria, archaea, fungi, and viruses. These microorganisms …

Background Parkinson's disease is characterized by a high burden of gastrointestinal
comorbidities, especially constipation and reduced colonic transit time, and by gut microbiota …

A Saskatchewan multi-incident family was clinically characterized with Parkinson disease (PD)
and Lewy body pathology. PD segregates as an autosomal-dominant trait, which could …

Background Gut microbiome alterations have been reported in Parkinson's disease (PD), but
with heterogenous findings, likely due to differences in study methodology and population. …

Methods Parkinson Canada sponsored this guideline update; the Knowledge Synthesis
Group at the Ottawa Hospital Research Institute, Ottawa (PB, BH), led the methodology used. …

Background The objective of this study was to examine the effects of aerobic exercise on
evoked dopamine release and activity of the ventral striatum using positron emission …

Objective: To assess effects of caffeine on Parkinson disease (PD). Methods: In this multicenter
parallel-group controlled trial, patients with PD with 1–8 years disease duration, Hoehn & …

Background The MIND diet has been linked with prevention of Alzheimer's disease and
cognitive decline but has not been fully assessed in the context of Parkinson's disease (PD). The …

Like many neurodegenerative diseases, the clinical symptoms of Parkinsons disease (PD)
do not manifest until significant progression of the disease has already taken place, …