[HTML][HTML] Cultured epidermal autografts from clinically revertant skin as a potential wound treatment for recessive dystrophic epidermolysis bullosa
…, H Hayashi, K Ono, M Inoie, S Takashima… - Journal of Investigative …, 2019 - Elsevier
Inherited skin disorders have been reported recently to have sporadic normal-looking areas,
where a portion of the keratinocytes have recovered from causative gene mutations (…
where a portion of the keratinocytes have recovered from causative gene mutations (…
Intravenous injection of muse cells as a potential therapeutic approach for epidermolysis bullosa
…, W Matsumura, S Takashima… - The Journal of …, 2021 - pubmed.ncbi.nlm.nih.gov
… 2 , Shota Takashima …
[HTML][HTML] Safety and dose-sparing effect of Japanese encephalitis vaccine administered by microneedle patch in uninfected, healthy adults (MNA-J): A randomised …
H Iwata, K Kakita, K Imafuku, S Takashima… - The Lancet …, 2022 - thelancet.com
Background It is unclear whether microneedle vaccinations of Japanese encephalitis virus
can induce sufficient neutralising antibodies and reduce the amount of vaccine needed. We …
can induce sufficient neutralising antibodies and reduce the amount of vaccine needed. We …
[HTML][HTML] Efficient gene reframing therapy for recessive dystrophic epidermolysis bullosa with CRISPR/Cas9
S Takashima, S Shinkuma, Y Fujita, T Nomura… - Journal of Investigative …, 2019 - Elsevier
The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system induces
site-specific double-strand breaks, which stimulate cellular DNA repair through either the …
site-specific double-strand breaks, which stimulate cellular DNA repair through either the …
The development of induced pluripotent stem cell-derived mesenchymal stem/stromal cells from normal human and RDEB epidermal keratinocytes
…, Y Fujita, W Matsumura, I Ujiie, S Takashima… - Journal of …, 2018 - Elsevier
Background Epidermolysis bullosa (EB) is a group of hereditary disorders caused by mutations
in the genes encoding structural molecules of the dermal-epidermal junction (DEJ). Cell-…
in the genes encoding structural molecules of the dermal-epidermal junction (DEJ). Cell-…
Collagen XVII deficiency alters epidermal patterning
…, M Watanabe, Y Fujimura, S Takashima… - Laboratory …, 2022 - nature.com
Vertebrates exhibit patterned epidermis, exemplified by scales/interscales in mice tails and
grooves/ridges on the human skin surface (microtopography). Although the role of …
grooves/ridges on the human skin surface (microtopography). Although the role of …
[PDF][PDF] Alternative mRNA splicing events and regulators in epidermal differentiation
Alternative splicing (AS) of messenger RNAs occurs in ∼95% of multi-exon human genes
and generates diverse RNA and protein isoforms. We investigated AS events associated with …
and generates diverse RNA and protein isoforms. We investigated AS events associated with …
Type XVII collagen interacts with the aPKC‐PAR complex and maintains epidermal cell polarity
…, H Kosumi, SI Osada, S Takashima… - Experimental …, 2021 - Wiley Online Library
Type XVII collagen (COL17) is a transmembrane protein expressed in the basal epidermis.
COL17 serves as a niche for epidermal stem cells, and although its reduction has been …
COL17 serves as a niche for epidermal stem cells, and although its reduction has been …
Hair follicle stem cell progeny heal blisters while pausing skin development
Injury in adult tissue generally reactivates developmental programs to foster regeneration,
but it is not known whether this paradigm applies to growing tissue. Here, by employing …
but it is not known whether this paradigm applies to growing tissue. Here, by employing …
Detection of revertant mosaicism in epidermolysis bullosa through Cas9‐targeted long‐read sequencing
Revertant mosaicism (RM) is a phenomenon in which inherited mutations are spontaneously
corrected in somatic cells. RM occurs in some congenital skin diseases, but genetic …
corrected in somatic cells. RM occurs in some congenital skin diseases, but genetic …
