User profiles for Shane Shapera

Shane Shapera

University of Toronto
Verified email at uhn.ca
Cited by 1926

Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled …

…, SA LeClercq, M Hyman, S Shapera… - The Lancet …, 2023 - thelancet.com
Background Interstitial lung disease is a known complication of rheumatoid arthritis, with a
lifetime risk of developing the disease in any individual of 7·7%. We aimed to assess the safety…

Ziritaxestat, a novel autotaxin inhibitor, and lung function in idiopathic pulmonary fibrosis: the ISABELA 1 and 2 randomized clinical trials

…, J Morisset, S Provencher, C Ryerson, S Shapera… - Jama, 2023 - jamanetwork.com
Importance There is a major need for effective, well-tolerated treatments for idiopathic
pulmonary fibrosis (IPF). Objective To assess the efficacy and safety of the autotaxin inhibitor …

Prevalence and characteristics of progressive fibrosing interstitial lung disease in a prospective registry

…, A Comes, JH Fisher, S Shapera… - European …, 2022 - Eur Respiratory Soc
Background Progressive fibrosing interstitial lung disease (PF-ILD) is characterised by
progressive physiological, symptomatic and/or radiographic worsening. The real-world …

Accuracy and reliability of internet resources for information on idiopathic pulmonary fibrosis

…, D O'Connor, AM Flexman, S Shapera… - American journal of …, 2016 - atsjournals.org
Rationale: Patients commonly use the Internet as a resource for health information; however,
no studies have evaluated the online information about idiopathic pulmonary fibrosis (IPF). …

[HTML][HTML] Acute exacerbations of progressive-fibrosing interstitial lung diseases

…, ML Padilla, J Roman, S Shapera - European …, 2018 - Eur Respiratory Soc
Acute exacerbation of interstitial lung disease (ILD) is associated with a poor prognosis and
high mortality. Numerous studies have documented acute exacerbation in idiopathic …

Practical considerations for the diagnosis and treatment of fibrotic interstitial lung disease during the coronavirus disease 2019 pandemic

…, JH Fisher, N Hambly, M Kolb, J Morisset, S Shapera… - Chest, 2020 - Elsevier
… Fisher MD g , Nathan Hambly MD h , Martin Kolb MD h , Julie Morisset MD i , Shane
Shapera MD g , Christopher J. Ryerson MD a b … Shapera, T. To, TK Marras, A. Gershon, S. …

[HTML][HTML] Phase 2 clinical trial of PBI-4050 in patients with idiopathic pulmonary fibrosis

…, H Manganas, CJ Ryerson, S Shapera… - European …, 2019 - Eur Respiratory Soc
PBI-4050 is a novel orally active small-molecule compound with demonstrated anti-fibrotic
activity in several models of fibrosis, including lung fibrosis. We present results from our first …

Procedure volume and mortality after surgical lung biopsy in interstitial lung disease

JH Fisher, S Shapera, T To, TK Marras… - European …, 2019 - Eur Respiratory Soc
Surgical volume–outcome relationships are well established but have not been studied in
patients with interstitial lung disease (ILD) undergoing surgical lung biopsy (SLB). Our study …

Impact of pretreatment interstitial lung disease on radiation pneumonitis and survival in patients treated with lung stereotactic body radiation therapy (SBRT)

D Glick, S Lyen, S Kandel, S Shapera, LW Le… - Clinical Lung Cancer, 2018 - Elsevier
Introduction The purpose of this study was to determine the impact of interstitial lung disease
(ILD) on radiation pneumonitis (RP) and overall survival (OS) in lung stereotactic body …

Treatment of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis

L Fidler, N Sitzer, S Shapera, PS Shah - Chest, 2018 - Elsevier
Background Gastroesophageal reflux (GER) is common in patients with idiopathic pulmonary
fibrosis (IPF) and has been proposed as a potential contributor to disease progression and …