User profiles for Sarah Spitz
Sarah SpitzMassachusetts Institute of Technology Verified email at mit.edu Cited by 497 |
[HTML][HTML] Monitoring the neurotransmitter release of human midbrain organoids using a redox cycling microsensor as a novel tool for personalized Parkinson's disease …
In this study, we have aimed at developing a novel electrochemical sensing approach
capable of detecting dopamine, the main biomarker in Parkinson's disease, within the highly …
capable of detecting dopamine, the main biomarker in Parkinson's disease, within the highly …
[HTML][HTML] Stiffness matters: fine-tuned hydrogel elasticity alters chondrogenic redifferentiation
B Bachmann, S Spitz, B Schädl, AH Teuschl… - … in Bioengineering and …, 2020 - frontiersin.org
Biomechanical cues such as shear stress, stretching, compression, and matrix elasticity are
vital in the establishment of next generation physiological in vitro tissue models. Matrix …
vital in the establishment of next generation physiological in vitro tissue models. Matrix …
[HTML][HTML] Bridging the academic–industrial gap: application of an oxygen and pH sensor-integrated lab-on-a-chip in nanotoxicology
Translation of advanced cell-based assays exhibiting a higher degree of automation,
miniaturization, and integration of complementary sensing functions is mainly limited by the …
miniaturization, and integration of complementary sensing functions is mainly limited by the …
Engineering of three-dimensional pre-vascular networks within fibrin hydrogel constructs by microfluidic control over reciprocal cell signaling
Reengineering functional vascular networks in vitro remains an integral part in tissue
engineering, since the incorporation of non-perfused tissues results in restricted nutrient supply …
engineering, since the incorporation of non-perfused tissues results in restricted nutrient supply …
[HTML][HTML] Establishment of a human three-dimensional chip-based chondro-synovial coculture joint model for reciprocal cross talk studies in arthritis research
…, IO Calvo, A Fischer, EI Reihs, S Spitz… - Lab on a Chip, 2021 - pubs.rsc.org
Rheumatoid arthritis is characterised by a progressive, intermittent inflammation at the
synovial membrane, which ultimately leads to the destruction of the synovial joint. The synovial …
synovial membrane, which ultimately leads to the destruction of the synovial joint. The synovial …
[HTML][HTML] Recent advances in additive manufacturing and 3D bioprinting for organs-on-A-chip and microphysiological systems
The re-creation of physiological cellular microenvironments that truly resemble complex in
vivo architectures is the key aspect in the development of advanced in vitro organotypic tissue …
vivo architectures is the key aspect in the development of advanced in vitro organotypic tissue …
Sensor‐integrated brain‐on‐a‐chip platforms: Improving the predictive validity in neurodegenerative research
S Spitz, S Schobesberger… - Bioengineering & …, 2023 - Wiley Online Library
Affecting millions of individuals worldwide, neurodegenerative diseases (NDDs) pose a
significant and growing health concern in people over the age of 60 years. Contributing to this …
significant and growing health concern in people over the age of 60 years. Contributing to this …
[HTML][HTML] Breaking the third wall: Implementing 3D-printing techniques to expand the complexity and abilities of multi-organ-on-a-chip devices
Y Goldstein, S Spitz, K Turjeman, F Selinger… - Micromachines, 2021 - mdpi.com
The understanding that systemic context and tissue crosstalk are essential keys for bridging
the gap between in vitro models and in vivo conditions led to a growing effort in the last …
the gap between in vitro models and in vivo conditions led to a growing effort in the last …
[HTML][HTML] A decade of organs-on-a-chip emulating human physiology at the microscale: a critical status report on progress in toxicology and pharmacology
Organ-on-a-chip technology has the potential to accelerate pharmaceutical drug development,
improve the clinical translation of basic research, and provide personalized intervention …
improve the clinical translation of basic research, and provide personalized intervention …
[HTML][HTML] Optical glucose sensor for microfluidic cell culture systems
S Fuchs, V Rieger, AØ Tjell, S Spitz… - Biosensors and …, 2023 - Elsevier
Glucose is the primary energy source of human cells. Therefore, monitoring glucose inside
microphysiological systems (MPS) provides valuable information on the viability and …
microphysiological systems (MPS) provides valuable information on the viability and …