CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion

…, S Farias, M Fatas, J Fiedorowicz, R Fullam, S Furtado… - Neurology, 2012 - AAN Enterprises
Objective: Age at onset of diagnostic motor manifestations in Huntington disease (HD) is
strongly correlated with an expanded CAG trinucleotide repeat. The length of the normal CAG …

Levodopa-induced changes in synaptic dopamine levels increase with progression of Parkinson's disease: implications for dyskinesias

…, V Sossi, Z Huang, S Furtado… - Brain, 2004 - academic.oup.com
Peak-dose dyskinesias are abnormal movements that usually occur 1 h after oral
administration of levodopa, and often complicate chronic treatment of Parkinson's disease. We …

Neuropathy as a potential complication of levodopa use in Parkinson's disease

C Toth, MS Brown, S Furtado… - Movement …, 2008 - Wiley Online Library
The presence and potential etiologies of peripheral neuropathy (PN) in patients with Parkinson's
Disease (PD) is unknown. We examined for presence of PN in patients with PD. From a …

Caffeine as symptomatic treatment for Parkinson disease (Café-PD) A randomized trial

…, L Joseph, M Moscovich, D Grimes, S Furtado… - Neurology, 2017 - AAN Enterprises
Objective: To assess effects of caffeine on Parkinson disease (PD). Methods: In this multicenter
parallel-group controlled trial, patients with PD with 1–8 years disease duration, Hoehn & …

Profile of families with parkinsonism‐predominant spinocerebellar ataxia type 2 (SCA2)

S Furtado, H Payami, PJ Lockhart… - … : official journal of the …, 2004 - Wiley Online Library
Spinocerebellar ataxia type 2 (SCA2) has been recognized recently as an uncommon cause
of parkinsonism, an alternate presentation to the typical cerebellar disorder. This research …

Relationship between trinucliotide repeats and neuropathological changes in Huntington's diease

S Furtado, O Suchowersky, NB Rewcastle… - Annals of …, 1996 - Wiley Online Library
The discovery of the Huntington's disease (HD) gene has provided the impetus to determine
the association between the triplet repeat sequences and clinical manifestations of the …

Beneficial effect of intranasal desmopressin for nocturnal polyuria in Parkinson's disease

O Suchowersky, S Furtado… - … disorders: official journal of …, 1995 - Wiley Online Library
Patients with Parkinson's disease (PD) are known to experience autonomic nervous system
dysfunction; this disruptive symptomatology includes urinary urgency, frequency, and …

Mild behavioral impairment is linked to worse cognition and brain atrophy in Parkinson disease

…, J Cheetham, I Kathol, JR Sarna, D Martino, S Furtado… - Neurology, 2019 - AAN Enterprises
Objective To evaluate the associations of mild behavioral impairment (MBI) with cognitive
deficits and patterns of gray matter changes in Parkinson disease (PD). Methods Sixty patients …

Prevalence of problem and pathological gambling in Parkinson's disease

D Crockford, J Quickfall, S Currie, S Furtado… - Journal of Gambling …, 2008 - Springer
Pathological gambling (PG) has been identified in patients with Parkinson’s disease (PD)
treated with dopamine agonists suggesting that dysregulation of brain dopaminergic activity …

VMAT2 binding is elevated in dopa‐responsive dystonia: visualizing empty vesicles by PET

R De La Fuente‐Fernández, S Furtado, M Guttman… - Synapse, 2003 - Wiley Online Library
Dopa‐responsive dystonia (DRD) is a lifelong disorder in which dopamine deficiency is not
associated with neuronal loss and therefore it is an ideal human model for investigating the …