Unintended medication discrepancies at the time of hospital admission

PL Cornish, SR Knowles, R Marchesano… - Archives of internal …, 2005 - jamanetwork.com
Background Prior studies suggest that unintended medication discrepancies that represent
errors are common at the time of hospital admission. These errors are particularly worthy of …

Frequency, type and clinical importance of medication history errors at admission to hospital: a systematic review

VC Tam, SR Knowles, PL Cornish, N Fine… - Cmaj, 2005 - Can Med Assoc
Background: Over a quarter of hospital prescribing errors are attributable to incomplete
medication histories being obtained at the time of admission. We undertook a systematic review …

Idiosyncratic drug reactions: the reactive metabolite syndromes

SR Knowles, J Uetrecht, NH Shear - The Lancet, 2000 - thelancet.com
Idiosyncratic drug reactions are unpredictable reactions that can result in significant morbidity
and mortality. Severe idiosyncratic drug reactions are often characterised by fever and …

Anticonvulsant hypersensitivity syndrome: incidence, prevention and management

SR Knowles, LE Shapiro, NH Shear - Drug safety, 1999 - Springer
Although the anticonvulsant hypersensitivity syndrome was first described in 1950,
confusion still abounds regarding the syndrome. The triad of fever, rash and internal organ …

Gender differences in adverse drug reactions

C Tran, SR Knowles, BA Liu… - The Journal of Clinical …, 1998 - Wiley Online Library
The objective of this study is to identify gender‐related differences in the types of symptoms
and drugs reported to cause an adverse drug reaction. Patient data from the Sunnybrook …

Comparative safety of tetracycline, minocycline, and doxycycline

LE Shapiro, SR Knowles, NH Shear - Archives of dermatology, 1997 - jamanetwork.com
Background: Because minocycline can cause serious adverse events including hypersensitivity
syndrome reaction (HSR), serum sicknesslike reaction (SSLR), and druginduced lupus, …

[HTML][HTML] Ribavirin in the treatment of SARS: A new trick for an old drug?

G Koren, S King, S Knowles, E Phillips - Cmaj, 2003 - Can Med Assoc
* The treatment dose of ribavirin has been reduced significantly from earlier recommendations
because of a lack of information to support the in vitro efficacy of ribavirin against the …

Serious adverse reactions induced by minocycline: report of 13 patients and review of the literature

SR Knowles, L Shapiro, NH Shear - Archives of dermatology, 1996 - jamanetwork.com
Background: Minocycline has been reported to cause serious, albeit rare, adverse events,
including serum sickness—like reaction, hypersensitivity syndrome reaction, and drug-…

Incidence of toxic epidermal necrolysis and Stevens-Johnson Syndrome in an HIV cohort: an observational, retrospective case series study

N Mittmann, SR Knowles, M Koo, NH Shear… - American journal of …, 2012 - Springer
Background: The incidence of Stevens-Johnson syndrome (SJS) and toxic epidermal
necrolysis (TEN) has been reported to be between 0.95 and 1 per 1000 individuals with AIDS. …

Utility of patch testing in patients with hypersensitivity syndromes associated with abacavir

EJ Phillips, JR Sullivan, SR Knowles, NH Shear - Aids, 2002 - journals.lww.com
Highly active antiretroviral therapy (HAART) suppresses viral replication and augments CD4
T cell counts. HAART-associated immune restoration is often difficult to predict. We verified …