The prevalence of allergic airway diseases such as asthma and rhinitis has increased
dramatically to epidemic proportions worldwide. Besides air pollution from industry derived …

Airway remodeling encompasses the structural alterations in asthmatic compared with
normal airways. Airway remodeling in asthmatic patients involves a wide array of …

TGF-β is one of the main mediators involved in tissue remodeling in the asthmatic lung. This
profibrotic cytokine is produced by a number of cells, including macrophages, epithelial cells…

INTRODUCTION Clinical outcomes of human severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus disease 2019 (…

Chronic mucocutaneous candidiasis disease (CMCD) is characterized by recurrent or persistent
infections of the skin, nails, and oral and genital mucosae caused by Candida albicans …

Chronic mucocutaneous candidiasis disease (CMCD) may be caused by autosomal dominant
(AD) IL-17F deficiency or autosomal recessive (AR) IL-17RA deficiency. Here, using whole…

Most patients with autoimmune polyendocrine syndrome type I (APS-I) display chronic
mucocutaneous candidiasis (CMC). We hypothesized that this CMC might result from …

Background The genetic analysis of human primary immunodeficiencies has defined the
contribution of specific cell populations and molecular pathways in the host defense against …

ISG15 is an interferon (IFN)-α/β–inducible, ubiquitin-like intracellular protein. Its conjugation
to various proteins (ISGylation) contributes to antiviral immunity in mice. Here, we describe …

Autosomal recessive interleukin-1 receptor-associated kinase (IRAK)-4 and myeloid differentiation
factor (MyD) 88 deficiencies impair Toll-like receptor (TLR)-and interleukin-1 receptor-…