Hormone interactions regulating energy balance during pregnancy

SR Ladyman, RA Augustine… - Journal of …, 2010 - Wiley Online Library
Appetite and food intake are increased during pregnancy, comprising an adaptive response
that facilitates energy storage in preparation for the high metabolic demands of pregnancy …

From feeding one to feeding many: hormone‐induced changes in bodyweight homeostasis during pregnancy

RA Augustine, SR Ladyman… - The Journal of …, 2008 - Wiley Online Library
… is also an α-MSH-resistant state (SR Ladyman, unpublished data). Other animal models of
… mRNA did not change during pregnancy (SR Ladyman, unpublished data), although other …

Hormonal induction of leptin resistance during pregnancy

DR Grattan, SR Ladyman, RA Augustine - Physiology & behavior, 2007 - Elsevier
Despite elevated plasma leptin, food intake is increased during pregnancy leading to fat
deposition. We have demonstrated that intracerebroventricular (icv) leptin is unable to suppress …

Prolactin action in the medial preoptic area is necessary for postpartum maternal nursing behavior

RSE Brown, M Aoki, SR Ladyman… - Proceedings of the …, 2017 - National Acad Sciences
Pregnancy hormones, such as prolactin, sensitize neural circuits controlling parental interactions
to induce timely activation of maternal behaviors immediately after parturition. While the …

Region-specific reduction in leptin-induced phosphorylation of signal transducer and activator of transcription-3 (STAT3) in the rat hypothalamus is associated with …

SR Ladyman, DR Grattan - Endocrinology, 2004 - academic.oup.com
Leptin concentrations increase during pregnancy, but this does not prevent the pregnancy-induced
increase in food intake, suggesting a state of leptin resistance. This study …

Suppression of leptin receptor messenger ribonucleic acid and leptin responsiveness in the ventromedial nucleus of the hypothalamus during pregnancy in the rat

SR Ladyman, DR Grattan - Endocrinology, 2005 - academic.oup.com
Pregnancy in the rat is a state of leptin resistance associated with impaired leptin signal
transduction in the hypothalamus. The aim of this study was to determine whether this leptin-…

Metabolic functions of prolactin: Physiological and pathological aspects

…, B Brie, E Sorianello, SR Ladyman… - Journal of …, 2020 - Wiley Online Library
Prolactin is named after its vital role of promoting milk production during lactation, although it
has been implicated in multiple functions within the body, including metabolism and energy …

Prolactin transport into mouse brain is independent of prolactin receptor

…, RE Herbison, PJ Knowles, SR Ladyman… - The FASEB …, 2016 - Wiley Online Library
The anterior pituitary hormone prolactin exerts important physiologic actions in the brain.
However, the mechanism by which prolactin crosses the blood‐brain barrier and enters the …

Central regulation of glucose homeostasis

A Tups, J Benzler, D Sergi, SR Ladyman… - Comprehensive …, 2011 - Wiley Online Library
The ability of the brain to directly control glucose levels in the blood independently of its effects
on food intake and body weight has been known ever since 1854 when Claude Bernard, …

Conditional deletion of the prolactin receptor reveals functional subpopulations of dopamine neurons in the arcuate nucleus of the hypothalamus

…, CM Larsen, P Knowles, SR Ladyman… - Journal of …, 2016 - Soc Neuroscience
Tuberoinfundibular dopamine (TIDA) neurons, known as neuroendocrine regulators of
prolactin secretion from the pituitary gland, also release GABA within the hypothalamic arcuate …