[HTML][HTML] High concentration of serum aspartate aminotransferase in older underweight people: results of the Kanagawa Investigation of the Total Check-Up Data from …

M Shibata, K Nakajima, R Higuchi, T Iwane… - Journal of clinical …, 2019 - mdpi.com
Background: Aspartate aminotransferase (AST) is pivotal in amino acid metabolism. However,
the serum activity of AST, which leaks from multiple organs, including liver and skeletal …

An autopsy case of peliosis hepatis with X-linked myotubular myopathy

…, N Takahashi, A Koyama, R Katsuragi-Go, R Higuchi… - Legal Medicine, 2019 - Elsevier
This report describes the autopsy case of a 4-year-old boy who died from hepatic hemorrhage
and rupture caused by peliosis hepatis with X-linked myotubular myopathy. Peliosis …

Kanagawa Investigation of the Total Check-up Data from the National database (KITCHEN): Protocol for data-driven population-based repeated cross-sectional and 6 …

K Nakajima, T Iwane, R Higuchi, M Shibata… - BMJ open, 2019 - bmjopen.bmj.com
Introduction The unmitigated incidence of cardiometabolic diseases, such as type 2 diabetes
and metabolic syndrome, has gained attention in Japan. ‘Big data’ can be useful to clarify …

[HTML][HTML] Copy number variation of the salivary amylase gene and glucose metabolism in healthy young Japanese women

R Higuchi, T Iwane, A Iida… - Journal of Clinical …, 2020 - ncbi.nlm.nih.gov
Background Many studies have shown that low copy number variation (CNV) of the salivary
amylase gene (AMY1) and low serum amylase concentration are associated with impaired …

[HTML][HTML] Fasting biochemical hypoglycemia and related-factors in non-diabetic population: Kanagawa Investigation of Total Check-up Data from National Database-8

K Tanaka, R Higuchi, K Mizusawa… - World Journal of …, 2021 - ncbi.nlm.nih.gov
BACKGROUND In healthy people, the lowest daily blood glucose concentration is usually
observed in the early morning, after overnight fasting. However, the clinical relevance and the …

[HTML][HTML] Association of serum high-density lipoprotein cholesterol with high blood pressures at checkup: results of kanagawa investigation of total checkup data from …

K Nakajima, M Igata, R Higuchi, K Tanaka… - Journal of Clinical …, 2021 - mdpi.com
Background: although high-density lipoprotein has cardioprotective effects, the association
between serum high-density lipoprotein cholesterol (HDL-C) and hypertension is poorly …

[HTML][HTML] Potential common factors associated with predisposition to common cold in middle-aged and elderly Japanese: a community-based cross-sectional study

M Shibata, T Iwane, R Higuchi, K Suwa, K Nakajima - Medicine, 2018 - journals.lww.com
People worldwide frequently catch a common cold, which occasionally develops into secondary
severe conditions such as pneumonia. However, it is unclear whether predisposition to …

[HTML][HTML] The association of low serum salivary and pancreatic amylases with the increased use of lipids as an energy source in non-obese healthy women

K Nakajima, R Higuchi, T Iwane, A Iida - BMC Research Notes, 2020 - Springer
Objective It is unknown whether low serum levels of salivary and pancreatic amylases are
associated with the high combustion of carbohydrates or lipids for energy. Elevated blood …

[HTML][HTML] Detection and morphological analysis of micro-ruptured cortical arteries in subdural hematoma: Three-dimensional visualization using the tissue-clearing …

…, R Katsuragi-Go, N Nishikawa-Harada, R Higuchi… - Diagnostics, 2022 - mdpi.com
One of the causes of bleeding in subdural hematoma is cortical artery rupture, which is difficult
to detect at autopsy. Therefore, reports of autopsy cases with this condition are limited and …

Association between extremely high high-density lipoprotein-cholesterol and hypertensive retinopathy: results of a cross-sectional study from Kanagawa Investigation …

K Nakajima, R Higuchi, K Mizusawa, T Nakamura - BMJ open, 2021 - bmjopen.bmj.com
Objectives Doubt has been cast on the atheroprotective effect of very high high-density
lipoprotein cholesterol (HDL-C). Hypertensive retinopathy (HR) is caused by persistent systemic …