Isoproterenol hydrochloride sensitivity was measured from dose/response curves to rapid
intravenous injections as the dose required to increase the heart rate by 25 beats per minute (…

Nine patients on chronic treatment with propranolol for essential hypertension for 3 months
or longer were studied after abrupt discontinuation of the drug. Each patient demonstrated …

Background The way in which dissemination of evidence changes medical practice needs
to be better understood. Controversy about calcium-channel blockers (CCB) in the past 3 …

Three groups of hypertensive patients were studied after they had received one of the three
pharmacologically different beta blockers for at least 1 month: pindolol, 10 mg twice a day (n …

To determine the role of liver dysfunction in theophylline toxicity, we administered single
intravenous doses of the drug to nine patients with cirrhosis and observed its disposition over a …

Abrupt withdrawal of propranolol may be followed by a “propranolol withdrawal syndrome”
due, at least in part, to enhanced beta adrenergic sensitivity. Tapering propranolol dosage is …

Eight patients taking metoprolol (300 mg/day) for essential hypertension were studied after
abrupt withdrawal and placebo replacement of the drug. A 52% average rebound increase in …

We present a specific, sensitive high-pressure liquidchromatographic assay for theophylline
in plasma. Only 0.5 ml of plasma is required for each determination, and the lower limit of …

Twenty‐four patients with established benign prostaue hypertrophy (BPH) uiere treated at
random in a double‐blind manner with one of two drug schedules: medrogestone [or 24 …

Randomized controlled trials are the best way of determining whether a cause–effect relation
exists between treatment and outcome. 2 They are also one of the best ways to determine …