Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-11C-Methyl]-(−)-Cocaine PET Studies in Human Subjects

…, DJ Schlyer, RR MacGregor… - Journal of Cerebral …, 1990 - journals.sagepub.com
A graphical method of analysis applicable to ligands that bind reversibly to receptors or
enzymes requiring the simultaneous measurement of plasma and tissue radioactivities for …

[PDF][PDF] Metabolic trapping as a principle of radiopharmaceutical design: some factors responsible for the biodistribution of [18F] 2-deoxy-2-fluoro-D-glucose

…, JS Fowler, NI Gutterson, RR MacGregor… - Journal of Nuclear …, 1978 - Soc Nuclear Med
METHODS Radiopharmaceufical synthesis.[18F] 2-deoxy-2-fluoro-D-glucose (Fi 8-DO) was
prepared as pre viously described (2, 1 1, 12). Typical specific activi ties used in these …

Brain monoamine oxidase A inhibition in cigarette smokers

…, C Shea, D Alexoff, RR MacGregor… - Proceedings of the …, 1996 - National Acad Sciences
Several studies have documented a strong association between smoking and depression.
Because cigarette smoke has been reported to inhibit monoamine oxidase (MAO) A in vitro …

Imaging endogenous dopamine competition with [11C]raclopride in the human brain

…, J Lieberman, B Angrist, N Pappas, R MacGregor… - Synapse, 1994 - Wiley Online Library
This study images dopamine release in response to a neurochemically specific challenge
with the psychostimulant drug methylphenidate. Changes in synaptic dopamine induced by …

Inside the LOOM description classifier

RM MacGregor - ACM Sigart Bulletin, 1991 - dl.acm.org
This paper presents a symbol level account of some of the representation and reasoning
structures within the LOOM knowledge representation system. Reasoning in LOOM centers …

[HTML][HTML] The disease-associated r (GGGGCC) n repeat from the C9orf72 gene forms tract length-dependent uni-and multimolecular RNA G-quadruplex structures

K Reddy, B Zamiri, SYR Stanley, RB Macgregor… - Journal of Biological …, 2013 - ASBMB
Certain DNA and RNA sequences can form G-quadruplexes, which can affect promoter activity,
genetic instability, RNA splicing, translation, and neurite mRNA localization. Amyotrophic …

A basic model of electronic commerce adoption barriers: A study of regional small businesses in Sweden and Australia

RC MacGregor, L Vrazalic - Journal of small business and enterprise …, 2005 - emerald.com
Purpose – To develop a basic model of e‐commerce adoption barriers to small businesses
located in regional areas of developed countries. Design/methodology/approach – An …

Electronic commerce adoption barriers in small to medium-sized enterprises (SMEs) in developed and developing countries: A cross-country comparison

M Kartiwi, RC MacGregor - Journal of Electronic Commerce in …, 2007 - igi-global.com
Today, electronic commerce (e-commerce) has been utilised as a rapid vehicle to transform
the world into an information society. In the business environment, e-commerce has made …

Mapping cocaine binding sites in human and baboon brain in vivo

…, AP Wolf, SL Dewey, DJ Schlyer, RR MacGregor… - Synapse, 1989 - Wiley Online Library
The first direct measurements of cocaine binding in the brain of normal human volunteers and
baboons have been made by using positron emission tomography (PET) and tracer doses …

Estimation of the polarity of the protein interior by optical spectroscopy

RB Macgregor, G Weber - Nature, 1986 - nature.com
Crystallographic studies of myoglobin have shown that the haem pocket is lined with nonpolar
amino-acid residues 1 . In order to estimate the true polarity of the interior of proteins, …