SMALL eye (Sey) in mouse is a semidominant mutation which in the homozygous condition
results in the complete lack of eyes and nasal primordia. On the basis of comparative …

Unequivocal identification of the full composition of a gene is made difficult by the cryptic
nature of regulatory elements. Regulatory elements are notoriously difficult to locate and may …

Small eye (Sey) mice homozygous for mutations in the Pax-6 gene have no lenses and no
nasal cavities. We have examined the ontogeny of eye and nasal defects in Sey/Sey embryos …

We have previously mapped the human azoospermia factor to a deletion in Y chromosome
interval 6 (subinterval XII-XIV). We now report the isolation and characterization of a gene …

Preaxial polydactyly (PPD) is a common limb malformation in human. A number of
polydactylous mouse mutants indicate that misexpression of Shh is a common requirement for …

The presence of ribonucleotides in genomic DNA is undesirable given their increased
susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize and process such …

The epicardial epithelial-mesenchymal transition (EMT) is hypothesized to generate
cardiovascular progenitor cells that differentiate into various cell types, including coronary smooth …

Two families of homeo box-containing genes have been identified in mammals to date, the
Antennapedia- and engrailed-like homeo boxes, based on the sequence similarity to those …

Notch and the m9/10 gene (groucho) of the Enhancer of split (E(spl)) complex are members
of the “Notch group” of genes, which is required for a variety of cell fate choices in Drosophila…

Aicardi–Goutières syndrome ( AGS ) provides a monogenic model of nucleic acid‐mediated
inflammation relevant to the pathogenesis of systemic autoimmunity. Mutations that impair …