Systemic corticosteroids play an integral role in the management of many inflammatory and
immunologic conditions, but these agents are also associated with serious risks. …

Background Thymic stromal lymphopoietin (TSLP) is an epithelial-cell–derived cytokine that
may be important in initiating allergic inflammation. AMG 157 is a human anti-TSLP …

… , I had the great good fortune to meet Richard Leigh. Richard is a novelist and short-story …
of medieval warrior-monks had already awakened Richard’s profound interest, and he had …

Background Interleukin 13 is a central mediator of asthma. Tralokinumab is a human
interleukin-13 neutralising monoclonal antibody. We aimed to assess the efficacy and safety of two …

Saccades are rapid eye movements that move the line of sight between successive points of
fixation; they are among the best understood of movements, possessing dynamic properties …

Induced sputum cell counts provide a relatively noninvasive method to evaluate the presence,
type, and degree of inflammation in the airways of the lungs. Their interpretation requires …

Background Many asthmatic patients exhibit sputum eosinophilia associated with
exacerbations. Benralizumab targets eosinophils by binding IL-5 receptor α, inducing apoptosis …

Background Benralizumab is an interleukin-5 receptor α-directed cytolytic monoclonal
antibody that has been shown to safely reduce exacerbations and improve lung function for …

BACKGROUND: In 2010, the Canadian Thoracic Society (CTS) published a Consensus
Summary for the diagnosis and management of asthma in children six years of age and older, …

Purpose To characterize intracranial plaque inflammation in vivo by using three-dimensional
(3D) high-spatial-resolution contrast material–enhanced black-blood (BB) magnetic …