Background Cancer stem cells (CSCs) are thought to be responsible for tumor regeneration
after chemotherapy, although direct confirmation of this remains forthcoming. We therefore …

We have recently demonstrated that cytolysis of human melanoma cells by immune effectors
(both NK and T cells) is associated with release of the nuclear chromatin protein, high …

Eosinophils (Eos) are found at increased numbers within necrotic areas of tumors. We show
that necrotic material from cell lysates containing damage-associated molecular pattern …

The ability of cancer cells to evade apoptosis may permit survival of a recombinant vaccinia
lacking antiapoptotic genes in cancer cells compared with normal cells. We have explored …

Screening expressed sequence tag databases for endothelial-specific homologs to human
junctional adhesion molecule (JAM) and A33-Ag, we identified a protein of 298 aa that …

Substantial attention has been paid to the role of the toll-like receptor (TLR) ligands of late
and their role in regulating the innate immune response. They serve as exogenous danger …

High mobility group box 1 (HMGB1) is a NF released extracellularly as a late mediator of
lethality in sepsis and as an early mediator of inflammation following injury. Here we …

We have constructed expression vectors for Chinese hamster ovary (CHO) cells that
produce both selectable marker and recombinant cDNA from a single primary transcript via …

High mobility group box 1 (HMGB1) is one of the recently defined damage-associated
molecular pattern molecules, passively released from necrotic cells and secreted by activated …

High mobility group B1 (HMGB1) and its counter-receptor, receptor for advanced glycation
end products (RAGE), represent suitable targets for investigation, integrating many aspects of …