Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on the histone
H3 tail at important regulatory regions in the genome and thereby impart crucial functions …

Over the last decade, human cell transplantation and neural stem cell trials have examined
the feasibility and safety of these potential therapies for treatment of a variety of neurological …

Purpose To describe the spectral-domain optical coherence tomography (SD OCT) features
of peripheral retinal findings using an ultra-widefield (UWF) steering technique to image the …

Major advances in the study of inherited retinal diseases (IRDs) have placed efforts to develop
treatments for these blinding conditions at the forefront of the emerging field of precision …

Background Vitreoretinal lymphoma (VRL), the most common lymphoma of the eye, is a rare
form of primary CNS lymphoma (PCNSL). Most frequently a high-grade diffuse large B cell …

The interconversion between naive and primed pluripotent states is accompanied by drastic
epigenetic rearrangements. However, it is unclear whether intrinsic epigenetic events can …

Importance Patient perceptions regarding the risks of obtaining in-person ophthalmic care
during the coronavirus disease 2019 (COVID-19) pandemic may affect adherence to …

PRDM16 is a transcription co-factor that plays critical roles in development of brown adipose
tissue, as well as maintenance of adult hematopoietic and neural stem cells. Here we report …

Importance Recent studies have linked a vision-threatening maculopathy with long-term
use of pentosan polysulfate sodium (PPS). Objective To evaluate the disease course in PPS-…

Non-Hodgkin lymphoma of the orbit and ocular adnexa is the most common primary orbital
malignancy. Treatments for low- (extra-nodal marginal zone and follicular lymphomas) and …