Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status
…, TR Cox, M Pajic, D Herrmann, P Timpson - Science …, 2021 - science.org
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic, chemoresistant malignancy
and is characterized by a dense, desmoplastic stroma that modulates PDAC progression. …
and is characterized by a dense, desmoplastic stroma that modulates PDAC progression. …
DEVELOPING 'HAZOP” METHODOLOGIES TO REFINE FIRE RISK ASSESSMENTS Hazop methodologies for fire risk
RJ TIMPSON - Abnormal Loading on Structures: Experimental …, 2000 - books.google.com
The purpose of this paper is to describe the techniques involved in the process of Hazard
and Operability studies (HAZOP). The document will then describe how this process could …
and Operability studies (HAZOP). The document will then describe how this process could …
Annexin A6 inhibits Ras signalling in breast cancer cells
SV De Muga, P Timpson, L Cubells, R Evans… - Oncogene, 2009 - nature.com
Overexpression of epidermal growth factor receptor (EGFR) is associated with enhanced
activation of wild-type (hyperactive) Ras in breast cancer. Little is known about the regulation of …
activation of wild-type (hyperactive) Ras in breast cancer. Little is known about the regulation of …
Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth …
P Timpson, AS Wilson, GM Lehrbach, RL Sutherland… - Cancer research, 2007 - AACR
The CTTN gene (formerly designated EMS1), encodes cortactin, a key regulator of dynamic
actin networks. Both CTTN and CCND1, the latter encoding the cell cycle regulator cyclin D1…
actin networks. Both CTTN and CCND1, the latter encoding the cell cycle regulator cyclin D1…
The general practitioner as sports physician.
RJ Timpson - Canadian Medical Association Journal, 1977 - ncbi.nlm.nih.gov
General practitioners must become more knowledgeable about sports medicine in order
both to treat the injured athlete and to provide better rehabilitative treatment and advice on …
both to treat the injured athlete and to provide better rehabilitative treatment and advice on …
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
…, K Stark, ML Tammesoo, TM Teslovich, NJ Timpson… - Nature …, 2010 - nature.com
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …
FAK signaling in human cancer as a target for therapeutics
Focal adhesion kinase (FAK) is a key regulator of growth factor receptor- and integrin-mediated
signals, governing fundamental processes in normal and cancer cells through its kinase …
signals, governing fundamental processes in normal and cancer cells through its kinase …
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Through genome-wide association meta-analyses of up to 133,010 individuals of European
ancestry without diabetes, including individuals newly genotyped using the Metabochip, we …
ancestry without diabetes, including individuals newly genotyped using the Metabochip, we …
Rural Practice
RJ Timpson - Canadian Family Physician, 1968 - ncbi.nlm.nih.gov
I would like to present some of my observations of practice in the north before pointing out
some possible solutions to improve the situation. The wideand varied general medicine which …
some possible solutions to improve the situation. The wideand varied general medicine which …
[HTML][HTML] Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records
The frequency of, and risk factors for, long COVID are unclear among community-based
individuals with a history of COVID-19. To elucidate the burden and possible causes of long …
individuals with a history of COVID-19. To elucidate the burden and possible causes of long …