Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status

…, TR Cox, M Pajic, D Herrmann, P Timpson - Science …, 2021 - science.org
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic, chemoresistant malignancy
and is characterized by a dense, desmoplastic stroma that modulates PDAC progression. …

DEVELOPING 'HAZOP” METHODOLOGIES TO REFINE FIRE RISK ASSESSMENTS Hazop methodologies for fire risk

RJ TIMPSON - Abnormal Loading on Structures: Experimental …, 2000 - books.google.com
The purpose of this paper is to describe the techniques involved in the process of Hazard
and Operability studies (HAZOP). The document will then describe how this process could …

Annexin A6 inhibits Ras signalling in breast cancer cells

SV De Muga, P Timpson, L Cubells, R Evans… - Oncogene, 2009 - nature.com
Overexpression of epidermal growth factor receptor (EGFR) is associated with enhanced
activation of wild-type (hyperactive) Ras in breast cancer. Little is known about the regulation of …

Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth …

P Timpson, AS Wilson, GM Lehrbach, RL Sutherland… - Cancer research, 2007 - AACR
The CTTN gene (formerly designated EMS1), encodes cortactin, a key regulator of dynamic
actin networks. Both CTTN and CCND1, the latter encoding the cell cycle regulator cyclin D1…

The general practitioner as sports physician.

RJ Timpson - Canadian Medical Association Journal, 1977 - ncbi.nlm.nih.gov
General practitioners must become more knowledgeable about sports medicine in order
both to treat the injured athlete and to provide better rehabilitative treatment and advice on …

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

…, K Stark, ML Tammesoo, TM Teslovich, NJ Timpson… - Nature …, 2010 - nature.com
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …

FAK signaling in human cancer as a target for therapeutics

BY Lee, P Timpson, LG Horvath, RJ Daly - Pharmacology & therapeutics, 2015 - Elsevier
Focal adhesion kinase (FAK) is a key regulator of growth factor receptor- and integrin-mediated
signals, governing fundamental processes in normal and cancer cells through its kinase …

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

…, B Sennblad, C Gieger, P Salo, M Perola, NJ Timpson… - Nature …, 2012 - nature.com
Through genome-wide association meta-analyses of up to 133,010 individuals of European
ancestry without diabetes, including individuals newly genotyped using the Metabochip, we …

Rural Practice

RJ Timpson - Canadian Family Physician, 1968 - ncbi.nlm.nih.gov
I would like to present some of my observations of practice in the north before pointing out
some possible solutions to improve the situation. The wideand varied general medicine which …

[HTML][HTML] Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records

…, K Tilling, CT Rentsch, NJ Timpson… - Nature …, 2022 - nature.com
The frequency of, and risk factors for, long COVID are unclear among community-based
individuals with a history of COVID-19. To elucidate the burden and possible causes of long …