User profiles for R. A. Hegele
Rob HegeleWestern University, Robarts Research Institute Verified email at robarts.ca Cited by 82657 |
Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society consensus panel statement on assessment, aetiology and …
Statin-associated muscle symptoms (SAMS) are one of the principal reasons for statin non-adherence
and/or discontinuation, contributing to adverse cardiovascular outcomes. This …
and/or discontinuation, contributing to adverse cardiovascular outcomes. This …
Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the …
…, CJ Packard, E Bruckert, RA Hegele… - European heart …, 2017 - academic.oup.com
Aims To appraise the clinical and genetic evidence that low-density lipoproteins (LDLs)
cause atherosclerotic cardiovascular disease (ASCVD). Methods and results We assessed …
cause atherosclerotic cardiovascular disease (ASCVD). Methods and results We assessed …
Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus …
…, OS Descamps, O Wiklund, RA Hegele… - European heart …, 2013 - academic.oup.com
Aims The first aim was to critically evaluate the extent to which familial hypercholesterolaemia
(FH) is underdiagnosed and undertreated. The second aim was to provide guidance for …
(FH) is underdiagnosed and undertreated. The second aim was to provide guidance for …
Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the …
Aims Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening condition
characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (…
characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (…
Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment
…, JC Defesche, OS Descamps, RA Hegele… - European heart …, 2015 - academic.oup.com
Familial hypercholesterolaemia (FH) is a common genetic cause of premature coronary heart
disease (CHD). Globally, one baby is born with FH every minute. If diagnosed and treated …
disease (CHD). Globally, one baby is born with FH every minute. If diagnosed and treated …
Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups …
Background Cardiovascular disease rates vary greatly between ethnic groups in Canada. To
establish whether this variation can be explained by differences in disease risk factors and …
establish whether this variation can be explained by differences in disease risk factors and …
Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies—a consensus …
Recent advances in human genetics, together with a large body of epidemiologic, preclinical,
and clinical trial results, provide strong support for a causal association between …
and clinical trial results, provide strong support for a causal association between …
2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult …
… We have included risk stratification for several inflammatory diseases, including
rheumatoid arthritis, psoriasis and systemic lupus erythematosis (SLE) (11-13). Such …
rheumatoid arthritis, psoriasis and systemic lupus erythematosis (SLE) (11-13). Such …
2012 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia for the prevention of cardiovascular disease in the …
TJ Anderson, J Grégoire, RA Hegele, P Couture… - Canadian Journal of …, 2013 - Elsevier
Many developments have occurred since the publication of the widely-used 2009 Canadian
Cardiovascular Society (CCS) Dyslipidemia guidelines. Here, we present an updated …
Cardiovascular Society (CCS) Dyslipidemia guidelines. Here, we present an updated …
2016 Canadian Cardiovascular Society guidelines for the management of dyslipidemia for the prevention of cardiovascular disease in the adult
Since the publication of the 2012 guidelines new literature has emerged to inform decision-making.
The 2016 guidelines primary panel selected a number of clinically relevant …
The 2016 guidelines primary panel selected a number of clinically relevant …