Purpose Targeted temperature management (TTM) may improve survival and functional
outcome in comatose survivors of out-of-hospital cardiac arrest (OHCA), though the optimal …

Rationale: Methodological sources of bias and suboptimal reporting contribute to irreproducibility
in preclinical science and may negatively affect research translation. Randomization, …

Background Small studies have implicated plasminogen activator inhibitor-1 (PAI-1) as a
predictor of cardiovascular events; however, these findings have been inconsistent. We sought …

Background : Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a widely
used form of mechanical circulatory support in patients with refractory cardiogenic shock. A …

Background Cardiogenic shock is associated with substantial morbidity and mortality. Although
inotropic support is a mainstay of medical therapy for cardiogenic shock, little evidence …

The COVID-19 pandemic began in early 2020 with major health consequences. While a need
to disseminate information to the medical community and general public was paramount, …

Objectives The aim of this study was to evaluate the outcome of transcatheter mitral valve
repair (TMVr) in patients with cardiogenic shock and significant mitral regurgitation (MR). …

Correspondence to: Benjamin Hibbert, MD, PhD, University of Ottawa Heart Institute, 40
Ruskin Street, H-4238, Ottawa, ONT, Canada K1Y 4W7. E-mail bhibbert@ ottawaheart. ca

Background: Incorporating focused cardiac ultrasonography (FoCUS) into clinical examination
could improve the diagnostic yield of bedside patient evaluation. Purpose: To compare …

Background Aortic valve stenosis is a progressive disorder with variable progression rates.
The factors affecting aortic stenosis (AS) progression remain largely unknown. Objectives …