Prospective validation of a 1-hour algorithm to rule-out and rule-in acute myocardial infarction using a high-sensitivity cardiac troponin T assay

…, M Freese, C Stelzig, L Krivoshei, P Hillinger… - Cmaj, 2015 - Can Med Assoc
Background: We aimed to prospectively validate a novel 1-hour algorithm using high-sensitivity
cardiac troponin T measurement for early rule-out and rule-in of acute myocardial …

Optimal cutoff levels of more sensitive cardiac troponin assays for the early diagnosis of myocardial infarction in patients with renal dysfunction

…, N Marti, Z Moreno Weidmann, P Hillinger… - Circulation, 2015 - Am Heart Assoc
Background— It is unknown whether more sensitive cardiac troponin (cTn) assays maintain
their clinical utility in patients with renal dysfunction. Moreover, their optimal cutoff levels in …

One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I

…, C Schumacher, L Krivoshei, P Hillinger… - The American journal of …, 2015 - Elsevier
Objective We aimed to prospectively derive and validate a novel 1h-algorithm using high-sensitivity
cardiac troponin I (hs-cTnI) for early rule-out and rule-in of acute myocardial infarction…

Direct comparison of 4 very early rule-out strategies for acute myocardial infarction using high-sensitivity cardiac troponin I

…, D Flores Widmer, J Fuhrmann, P Hillinger… - Circulation, 2017 - Am Heart Assoc
Background: Four strategies for very early rule-out of acute myocardial infarction using high-sensitivity
cardiac troponin I (hs-cTnI) have been identified. It remains unclear which strategy …

Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin

…, C Arnold, B Nelles, S Druey, P Haaf, P Hillinger… - Circulation, 2015 - Am Heart Assoc
Background— Misdiagnosis of acute myocardial infarction (AMI) may significantly harm
patients and may result from inappropriate clinical decision values (CDVs) for cardiac troponin (…

One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I

…, K Grimm, J Boeddinghaus, P Hillinger… - American heart …, 2016 - Elsevier
Objective We aimed to prospectively derive and validate a novel 0-/1-hour algorithm using
high-sensitivity cardiac troponin I (hs-cTnI) for the early “rule-out” and “rule-in” of acute …

Characterization of the observe zone of the ESC 2015 high-sensitivity cardiac troponin 0 h/1 h-algorithm for the early diagnosis of acute myocardial infarction

…, C Jaeger, K Grimm, Z Sabti, P Hillinger… - International journal of …, 2016 - Elsevier
Objective The novel high-sensitivity cardiac troponin (hs-cTn) 0 h/1 h-algorithm substantially
improves the early triage of patient's assigned “rule-out” or “rule-in” of acute myocardial …

Diurnal rhythm of cardiac troponin: consequences for the diagnosis of acute myocardial infarction

…, C Puelacher, J Daniel Neuhaus, P Hillinger… - Clinical …, 2016 - academic.oup.com
BACKGROUND Interpretation of serial high-sensitivity cardiac troponin (hs-cTn) measurements
for the diagnosis of acute myocardial infarction (AMI) assumes random fluctuation of hs-…

Direct comparison of cardiac myosin-binding protein C with cardiac troponins for the early diagnosis of acute myocardial infarction

…, Z Sabti, MR Giménez, K Wildi, P Hillinger… - Circulation, 2017 - Am Heart Assoc
Background: Cardiac myosin-binding protein C (cMyC) is a cardiac-restricted protein that is
more abundant than cardiac troponins (cTn) and is released more rapidly after acute …

Clinical effect of sex-specific cutoff values of high-sensitivity cardiac troponin T in suspected myocardial infarction

…, T Nestelberger, C Puelacher, P Hillinger… - JAMA …, 2016 - jamanetwork.com
Importance It is currently unknown whether the uniform (universal clinical practice for more
than 2 decades) or 2 sex-specific cutoff levels are preferable when using high-sensitivity …