Relaxation of imprinted genes in human cancer
S Rainier, LA Johnson, CJ Dobry, AJ Ping, PE Grundy… - Nature, 1993 - nature.com
GENOMIC imprinting, or parental allele-specific expression of genes, has been demonstrated
at the molecular level in insects and mice 1,2 but not in man. Imprinting as a potential …
at the molecular level in insects and mice 1,2 but not in man. Imprinting as a potential …
[PDF][PDF] Loss of heterozygosity for chromosomes 1p and 16q is an adverse prognostic factor in favorable-histology Wilms tumor: a report from the National Wilms Tumor …
PE Grundy, NE Breslow, S Li, E Perlman… - Journal of clinical …, 2005 - tofp.org
Purpose To determine if tumor-specific loss of heterozygosity (LOH) for chromosomes 1p or
16q is associated with a poorer prognosis for children with favorable-histology (FH) Wilms …
16q is associated with a poorer prognosis for children with favorable-histology (FH) Wilms …
ETV6-NTRK3 Gene Fusions and Trisomy 11 Establish a Histogenetic Link between Mesoblastic Nephroma and Congenital Fibrosarcoma
…, MJ Garnett, TJ Pysher, JB Beckwith, PE Grundy… - Cancer research, 1998 - AACR
Congenital mesoblastic nephroma (CMN) is an infantile spindle cell tumor of the kidney that
is subdivided into “classical” and “cellular” forms based on the degree of cellularity and …
is subdivided into “classical” and “cellular” forms based on the degree of cellularity and …
[PDF][PDF] Treatment of anaplastic histology Wilms' tumor: results from the fifth National Wilms' Tumor Study
…, JA Kalapurakal, ML Ritchey, PE Grundy… - J Clin …, 2006 - researchgate.net
… E, etoposide 3.3 mg/kg/d for 5 days; 100 mg/m2/d for patients … Grundy PE, Green DM,
Coppes MJ, et al: Renal tumors, in Pizzo PA, Poplack DG (eds): Principles and Practice of …
Coppes MJ, et al: Renal tumors, in Pizzo PA, Poplack DG (eds): Principles and Practice of …
Comparison between single-dose and divided-dose administration of dactinomycin and doxorubicin for patients with Wilms' tumor: a report from the National Wilms' …
…, JB Beckwith, JZ Finklestein, PE Grundy… - Journal of Clinical …, 1998 - ascopubs.org
PURPOSE The National Wilms' Tumor Study (NWTS)-4 was designed to evaluate the efficacy,
toxicity, and cost of administration of different regimens for the treatment of Wilms' tumor (…
toxicity, and cost of administration of different regimens for the treatment of Wilms' tumor (…
Loss of heterozygosity for chromosomes 16q and 1p in Wilms' tumors predicts an adverse outcome
PE Grundy, PE Telzerow, N Breslow, J Moksness… - Cancer research, 1994 - AACR
We have prospectively analyzed Wilms' tumors from 232 patients registered on the National
Wilms' Tumor Study for loss of heterozygosity (LOH) on chromosomes 11p, 16q, and 1p. …
Wilms' Tumor Study for loss of heterozygosity (LOH) on chromosomes 11p, 16q, and 1p. …
Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter its DNA-binding specificity
…, DI Loukinov, EM Pugacheva, EM Klenova, PE Grundy… - Cancer research, 2002 - AACR
CTCF is a widely expressed 11-zinc finger (ZF) transcription factor that is involved in
different aspects of gene regulation including promoter activation or repression, hormone-…
different aspects of gene regulation including promoter activation or repression, hormone-…
[HTML][HTML] Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour
…, EHR Olivieri, IW Cunha, U Tabori, PE Grundy… - Nature …, 2014 - nature.com
Wilms tumour (WT) is an embryonal kidney neoplasia for which very few driver genes have
been identified. Here we identify DROSHA mutations in 12% of WT samples (26/222) using …
been identified. Here we identify DROSHA mutations in 12% of WT samples (26/222) using …
Treatment of Wilms tumor relapsing after initial treatment with vincristine, actinomycin D, and doxorubicin. A report from the National Wilms Tumor Study Group
…, ML Ritchey, PRM Thomas, PE Grundy… - Pediatric blood & …, 2008 - Wiley Online Library
Objective We evaluated the use of alternating cycles of cyclophosphamide/etoposide and
carboplatin/etoposide in children entered on National Wilms Tumor Study (NWTS)‐5 who …
carboplatin/etoposide in children entered on National Wilms Tumor Study (NWTS)‐5 who …
Frequent hypomethylation in Wilms tumors of pericentromeric DNA in chromosomes 1 and 16
G Qu, PE Grundy, A Narayan, M Ehrlich - Cancer genetics and cytogenetics, 1999 - Elsevier
Rearrangements in the pericentromeric heterochromatin of chromosome 1 or 16 are often
found in many types of cancers, including Wilms tumors, and have been suggested to …
found in many types of cancers, including Wilms tumors, and have been suggested to …