Survival for childhood cancer has increased dramatically over the last 40 years with 5-year
survival rates now approaching 80%. For many diagnostic groups, rapid increases in survival …

Background Among patients in whom childhood cancer was diagnosed in the 1970s and
1980s, 18% of those who survived for 5 years died within the subsequent 25 years. In recent …

Difficulties with negotiating and achieving desired social outcomes in life may be exacerbated
by the experience of childhood cancer, including adverse effects from therapies used to …

Survivors of childhood cancer treated with anthracycline chemotherapy or chest radiation
are at an increased risk of developing congestive heart failure. In this population, congestive …

… Data analysis and interpretation: Paul C. Nathan, Mark L. Greenberg, Kirsten K. Ness,
Melissa M. … Final approval of manuscript: Paul C. …

DNA replication−associated mutations are repaired by two components: polymerase
proofreading and mismatch repair. The mutation consequences of disruption to both repair …

Background: Pain is one of the most common and distressing symptoms reported by adolescents
with cancer. Despite advancements in pain assessment and management research, …

With modern therapies and supportive care, survival of childhood cancer has increased
considerably. Patients who have survived cancers involving the central nervous system or who …

Childhood cancer survivors are at risk for medical and psychosocial late effects as a result
of their cancer and its therapy. Promotion of healthy lifestyle behaviors and provision of …

Background Treatments for childhood cancer have evolved over the past 50 years, with the
goal of maximising the proportion of patients who achieve long-term survival, while …