Objective: This report describes the participants and compares the acute and longer-term
treatment outcomes associated with each of four successive steps in the Sequenced Treatment …

OBJECTIVE: Selective serotonin reuptake inhibitors (SSRIs) are widely used to treat depression,
but the rates, timing, and baseline predictors of remission in “real world” patients are …

Chronic and recurrent pain not associated with a disease is very common in childhood and
adolescence, but studies of pain prevalence have yielded inconsistent findings. This …

STAR*D is a multisite, prospective, randomized, multistep clinical trial of outpatients with
nonpsychotic major depressive disorder. The study compares various treatment options for …

Background: The differential effectiveness of parent training has led researchers to examine
a variety of child, parent, and familial variables that may predict treatment response. Studies …

Under the auspices of the Initiative on Methods, Measurement, and Pain Assessment in
Clinical Trials (IMMPACT), 26 professionals from academia, governmental agencies, and the …

With the proliferation of multi-site neuroimaging studies, there is a greater need for handling
non-biological variance introduced by differences in MRI scanners and acquisition protocols…

Background Needle‐related procedures are a common source of pain and distress for
children. Several psychological (cognitive‐behavioral) interventions to help manage or reduce …

We systematically reviewed the patterns of Continuous Performance Test (CPT) errors of
omission and commission exhibited by normal children and children with Attention Deficit and …

Objective: More than 40% of patients with major depressive disorder do not achieve
remission even after two optimally delivered trials of antidepressant medications. This study …